α2-Adrenergic modulation of Ih in adult-born granule cells in the olfactory bulb
In the olfactory bulb (OB), a large population of axon-less inhibitory interneurons, the granule cells (GCs), coordinate network activity and tune the output of principal neurons, the mitral and tufted cells (MCs), through dendrodendritic interactions. Furthermore, GCs undergo neurogenesis throughou...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.1055569/full |
| _version_ | 1797959809092288512 |
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| author | Ruilong Hu Janam Shankar Grant Z. Dong Pablo S. Villar Ricardo C. Araneda |
| author_facet | Ruilong Hu Janam Shankar Grant Z. Dong Pablo S. Villar Ricardo C. Araneda |
| author_sort | Ruilong Hu |
| collection | DOAJ |
| description | In the olfactory bulb (OB), a large population of axon-less inhibitory interneurons, the granule cells (GCs), coordinate network activity and tune the output of principal neurons, the mitral and tufted cells (MCs), through dendrodendritic interactions. Furthermore, GCs undergo neurogenesis throughout life, providing a source of plasticity to the neural network of the OB. The function and integration of GCs in the OB are regulated by several afferent neuromodulatory signals, including noradrenaline (NA), a state-dependent neuromodulator that plays a crucial role in the regulation of cortical function and task-specific decision processes. However, the mechanisms by which NA regulates GC function are not fully understood. Here, we show that NA modulates hyperpolarization-activated currents (Ih) via the activation of α2-adrenergic receptors (ARs) in adult-born GCs (abGCs), thus directly acting on channels that play essential roles in regulating neuronal excitability and network oscillations in the brain. This modulation affects the dendrodendritic output of GCs leading to an enhancement of lateral inhibition onto the MCs. Furthermore, we show that NA modulates subthreshold resonance in GCs, which could affect the temporal integration of abGCs. Together, these results provide a novel mechanism by which a state-dependent neuromodulator acting on Ih can regulate GC function in the OB. |
| first_indexed | 2024-04-11T00:36:55Z |
| format | Article |
| id | doaj.art-5ca49b2fcf5d4c1e90a8f144129e4658 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-11T00:36:55Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-5ca49b2fcf5d4c1e90a8f144129e46582023-01-06T16:46:25ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-01-011610.3389/fncel.2022.10555691055569α2-Adrenergic modulation of Ih in adult-born granule cells in the olfactory bulbRuilong HuJanam ShankarGrant Z. DongPablo S. VillarRicardo C. AranedaIn the olfactory bulb (OB), a large population of axon-less inhibitory interneurons, the granule cells (GCs), coordinate network activity and tune the output of principal neurons, the mitral and tufted cells (MCs), through dendrodendritic interactions. Furthermore, GCs undergo neurogenesis throughout life, providing a source of plasticity to the neural network of the OB. The function and integration of GCs in the OB are regulated by several afferent neuromodulatory signals, including noradrenaline (NA), a state-dependent neuromodulator that plays a crucial role in the regulation of cortical function and task-specific decision processes. However, the mechanisms by which NA regulates GC function are not fully understood. Here, we show that NA modulates hyperpolarization-activated currents (Ih) via the activation of α2-adrenergic receptors (ARs) in adult-born GCs (abGCs), thus directly acting on channels that play essential roles in regulating neuronal excitability and network oscillations in the brain. This modulation affects the dendrodendritic output of GCs leading to an enhancement of lateral inhibition onto the MCs. Furthermore, we show that NA modulates subthreshold resonance in GCs, which could affect the temporal integration of abGCs. Together, these results provide a novel mechanism by which a state-dependent neuromodulator acting on Ih can regulate GC function in the OB.https://www.frontiersin.org/articles/10.3389/fncel.2022.1055569/fulldendrodendriticlateral inhibitionneurogenesisnoradrenalineolfactory bulb |
| spellingShingle | Ruilong Hu Janam Shankar Grant Z. Dong Pablo S. Villar Ricardo C. Araneda α2-Adrenergic modulation of Ih in adult-born granule cells in the olfactory bulb Frontiers in Cellular Neuroscience dendrodendritic lateral inhibition neurogenesis noradrenaline olfactory bulb |
| title | α2-Adrenergic modulation of Ih in adult-born granule cells in the olfactory bulb |
| title_full | α2-Adrenergic modulation of Ih in adult-born granule cells in the olfactory bulb |
| title_fullStr | α2-Adrenergic modulation of Ih in adult-born granule cells in the olfactory bulb |
| title_full_unstemmed | α2-Adrenergic modulation of Ih in adult-born granule cells in the olfactory bulb |
| title_short | α2-Adrenergic modulation of Ih in adult-born granule cells in the olfactory bulb |
| title_sort | α2 adrenergic modulation of ih in adult born granule cells in the olfactory bulb |
| topic | dendrodendritic lateral inhibition neurogenesis noradrenaline olfactory bulb |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.1055569/full |
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