Prognostic value of soluble angiopoietin-2 and soluble Tie-2 in Egyptian patients with acute myeloid leukemia
OBJECTIVE: Angiogenesis plays a critical role in the development and growth of solid tumors and hematologic malignancies. The system involving angiopoietin-2 [Ang-2] and its receptor Tie-2 appears to play an important role in tumor angiogenesis and in the biology of hematological and non-hematologic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2010-12-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-87059 |
| _version_ | 1797909184837058560 |
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| author | Mohamed A. Attia Sahar M. Hazzaa Salwa A. Essa Mahmoud F. Seleim |
| author_facet | Mohamed A. Attia Sahar M. Hazzaa Salwa A. Essa Mahmoud F. Seleim |
| author_sort | Mohamed A. Attia |
| collection | DOAJ |
| description | OBJECTIVE: Angiogenesis plays a critical role in the development and growth of solid tumors and hematologic malignancies. The system involving angiopoietin-2 [Ang-2] and its receptor Tie-2 appears to play an important role in tumor angiogenesis and in the biology of hematological and non-hematological malignancies. We evaluated the levels of soluble (s)Ang-2 and sTie-2 in acute myeloid leukemia (AML) patients and investigated the impact of their circulating levels on the overall survival in those patients. METHODS: Ang-2 and Tie-2 were measured in plasma samples from AML patients and controls using enzyme-linked immunosorbent assay (ELISA). RESULTS: The levels of sAng-2 and sTie-2 were significantly higher in AML patients (2382.1+-1586.1 pg/ml and 6.74+-3.47 ng/ml, respectively) than in controls (649.5+-402.6 pg/ml and 2.63+-0.57 ng/ml, respectively; p<0.01). AML patients with high levels of sAng-2 and sTie-2 (≥2500 pg/ml and ≥8 ng/ml, respectively) had significantly shorter overall survival than those patients with low levels (<2500 pg/ml and <8 ng/ml, respectively). CONCLUSION: The results of our study demonstrated the prognostic significance of circulating sAng-2 and sTie-2 in AML patients. Modulation of the angiopoietin / Tie-2 axis may be a promising approach to improve the outcome in those patients. |
| first_indexed | 2024-04-10T11:04:26Z |
| format | Article |
| id | doaj.art-5ca5db76d2ed4c0f8344a5ba960ade41 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:04:26Z |
| publishDate | 2010-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-5ca5db76d2ed4c0f8344a5ba960ade412023-02-15T16:19:31ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632010-12-0127428228810.5152/tjh.2010.50TJH-87059Prognostic value of soluble angiopoietin-2 and soluble Tie-2 in Egyptian patients with acute myeloid leukemiaMohamed A. Attia0Sahar M. Hazzaa1Salwa A. Essa2Mahmoud F. Seleim3Department Of Clinical Pathology, Tanta University Faculty Of Medicine, Tanta, EgyptDepartment Of Clinical Pathology, Tanta University Faculty Of Medicine, Tanta, EgyptDepartment Of Clinical Pathology, Tanta University Faculty Of Medicine, Tanta, EgyptDepartment Of Internal Medicine, Tanta University Faculty Of Medicine, Tanta, EgyptOBJECTIVE: Angiogenesis plays a critical role in the development and growth of solid tumors and hematologic malignancies. The system involving angiopoietin-2 [Ang-2] and its receptor Tie-2 appears to play an important role in tumor angiogenesis and in the biology of hematological and non-hematological malignancies. We evaluated the levels of soluble (s)Ang-2 and sTie-2 in acute myeloid leukemia (AML) patients and investigated the impact of their circulating levels on the overall survival in those patients. METHODS: Ang-2 and Tie-2 were measured in plasma samples from AML patients and controls using enzyme-linked immunosorbent assay (ELISA). RESULTS: The levels of sAng-2 and sTie-2 were significantly higher in AML patients (2382.1+-1586.1 pg/ml and 6.74+-3.47 ng/ml, respectively) than in controls (649.5+-402.6 pg/ml and 2.63+-0.57 ng/ml, respectively; p<0.01). AML patients with high levels of sAng-2 and sTie-2 (≥2500 pg/ml and ≥8 ng/ml, respectively) had significantly shorter overall survival than those patients with low levels (<2500 pg/ml and <8 ng/ml, respectively). CONCLUSION: The results of our study demonstrated the prognostic significance of circulating sAng-2 and sTie-2 in AML patients. Modulation of the angiopoietin / Tie-2 axis may be a promising approach to improve the outcome in those patients.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-87059ang-2tie-2amlelisa |
| spellingShingle | Mohamed A. Attia Sahar M. Hazzaa Salwa A. Essa Mahmoud F. Seleim Prognostic value of soluble angiopoietin-2 and soluble Tie-2 in Egyptian patients with acute myeloid leukemia Turkish Journal of Hematology ang-2 tie-2 aml elisa |
| title | Prognostic value of soluble angiopoietin-2 and soluble Tie-2 in Egyptian patients with acute myeloid leukemia |
| title_full | Prognostic value of soluble angiopoietin-2 and soluble Tie-2 in Egyptian patients with acute myeloid leukemia |
| title_fullStr | Prognostic value of soluble angiopoietin-2 and soluble Tie-2 in Egyptian patients with acute myeloid leukemia |
| title_full_unstemmed | Prognostic value of soluble angiopoietin-2 and soluble Tie-2 in Egyptian patients with acute myeloid leukemia |
| title_short | Prognostic value of soluble angiopoietin-2 and soluble Tie-2 in Egyptian patients with acute myeloid leukemia |
| title_sort | prognostic value of soluble angiopoietin 2 and soluble tie 2 in egyptian patients with acute myeloid leukemia |
| topic | ang-2 tie-2 aml elisa |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-87059 |
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