The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity
Introduction. Oral mucositis is one of the earliest and most frequent complications of radiation therapy or chemotherapy in patients diagnosed with oropharyngeal cancer. Because of this pathology, therapeutic interventions are most often used, thereby poor treatment is considered an etiological fact...
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| Format: | Article |
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ABV-press
2022-02-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/720 |
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| author | A. O. Sekretnaya I. A. Zaderenko S. Yu. Ivanov S. B. Alieva A. B. Dymnikov R. R. Kaledin H. Alsayed Hachem |
| author_facet | A. O. Sekretnaya I. A. Zaderenko S. Yu. Ivanov S. B. Alieva A. B. Dymnikov R. R. Kaledin H. Alsayed Hachem |
| author_sort | A. O. Sekretnaya |
| collection | DOAJ |
| description | Introduction. Oral mucositis is one of the earliest and most frequent complications of radiation therapy or chemotherapy in patients diagnosed with oropharyngeal cancer. Because of this pathology, therapeutic interventions are most often used, thereby poor treatment is considered an etiological factor of oral mucositis. Now, this issue is being actively studied in the world, but a unified algorithm for treatment and prevention of oral mucositis has not been formed.The study objective – is to evaluate the effect of titanium glycerosolvate aquacomplex in reducing the intensity of radiation induced reactions and reducing the frequency of interruptions.Materials and methods. 52 patients diagnosed with oropharyngeal cancer were included in this study, treated with radiotherapy or chemotherapy. For prophylaxis of severe stages of oral mucositis, 32 patients underwent standard symptomatic therapy (group 1, control group); 20 patients took titanium glycerosolvate aquacomplex in accordance with symptomatic therapy (group 2).Results. In the group 1 only 61.7 % of patients completed treatment. In the group 2 80 % of patients completely underwent antitumor therapy. At the same time, they developed oral mucositis of the I–II degree. Also, in the group of the studied drug, in 100 % of cases, therapy was performed without interruptions.Conclusion. Using titanium glycerosolvate aquacomplex for the prophylaxis of severe stages of oral mucositis during radiotherapy or chemotherapy of oropharyngeal cancer is effective and safe. It is also convenient from the medical and economic side, thanks to the ability to use it on an outpatient basis. |
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| format | Article |
| id | doaj.art-5ca6be0b293f4a2ab28533a632c705be |
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| issn | 2222-1468 2411-4634 |
| language | Russian |
| last_indexed | 2025-03-14T08:39:55Z |
| publishDate | 2022-02-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj.art-5ca6be0b293f4a2ab28533a632c705be2025-03-02T12:53:52ZrusABV-pressОпухоли головы и шеи2222-14682411-46342022-02-01114818510.17650/2222-1468-2021-11-4-81-85472The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavityA. O. Sekretnaya0I. A. Zaderenko1S. Yu. Ivanov2S. B. Alieva3A. B. Dymnikov4R. R. Kaledin5H. Alsayed Hachem6Peoples’ Friendship University of RussiaPeoples’ Friendship University of Russia; N.N. Blokhin National Medical Research Center of Onсology, Ministry of Health of RussiaPeoples’ Friendship University of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Onсology, Ministry of Health of RussiaPeoples’ Friendship University of RussiaN.N. Blokhin National Medical Research Center of Onсology, Ministry of Health of RussiaPeoples’ Friendship University of RussiaIntroduction. Oral mucositis is one of the earliest and most frequent complications of radiation therapy or chemotherapy in patients diagnosed with oropharyngeal cancer. Because of this pathology, therapeutic interventions are most often used, thereby poor treatment is considered an etiological factor of oral mucositis. Now, this issue is being actively studied in the world, but a unified algorithm for treatment and prevention of oral mucositis has not been formed.The study objective – is to evaluate the effect of titanium glycerosolvate aquacomplex in reducing the intensity of radiation induced reactions and reducing the frequency of interruptions.Materials and methods. 52 patients diagnosed with oropharyngeal cancer were included in this study, treated with radiotherapy or chemotherapy. For prophylaxis of severe stages of oral mucositis, 32 patients underwent standard symptomatic therapy (group 1, control group); 20 patients took titanium glycerosolvate aquacomplex in accordance with symptomatic therapy (group 2).Results. In the group 1 only 61.7 % of patients completed treatment. In the group 2 80 % of patients completely underwent antitumor therapy. At the same time, they developed oral mucositis of the I–II degree. Also, in the group of the studied drug, in 100 % of cases, therapy was performed without interruptions.Conclusion. Using titanium glycerosolvate aquacomplex for the prophylaxis of severe stages of oral mucositis during radiotherapy or chemotherapy of oropharyngeal cancer is effective and safe. It is also convenient from the medical and economic side, thanks to the ability to use it on an outpatient basis.https://ogsh.abvpress.ru/jour/article/view/720oral mucositistitanium glycerosolvate aquacomplexmetal structures |
| spellingShingle | A. O. Sekretnaya I. A. Zaderenko S. Yu. Ivanov S. B. Alieva A. B. Dymnikov R. R. Kaledin H. Alsayed Hachem The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity Опухоли головы и шеи oral mucositis titanium glycerosolvate aquacomplex metal structures |
| title | The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity |
| title_full | The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity |
| title_fullStr | The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity |
| title_full_unstemmed | The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity |
| title_short | The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity |
| title_sort | use of a titanium containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity |
| topic | oral mucositis titanium glycerosolvate aquacomplex metal structures |
| url | https://ogsh.abvpress.ru/jour/article/view/720 |
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