Compact and modular system architecture for a nano-resonator-mass spectrometer
Mass measurements in the mega-to giga-Dalton range are essential for the characterization of natural and synthetic nanoparticles, but very challenging to perform using conventional mass spectrometers. Nano-electro-mechanical system (NEMS) based MS has demonstrated unique capabilities for the analysi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1238674/full |
| _version_ | 1797671329359462400 |
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| author | Adrien Reynaud Wioletta Trzpil Louis Dartiguelongue Louis Dartiguelongue Vaitson Çumaku Vaitson Çumaku Thomas Fortin Thomas Fortin Marc Sansa Sebastien Hentz Christophe Masselon Christophe Masselon |
| author_facet | Adrien Reynaud Wioletta Trzpil Louis Dartiguelongue Louis Dartiguelongue Vaitson Çumaku Vaitson Çumaku Thomas Fortin Thomas Fortin Marc Sansa Sebastien Hentz Christophe Masselon Christophe Masselon |
| author_sort | Adrien Reynaud |
| collection | DOAJ |
| description | Mass measurements in the mega-to giga-Dalton range are essential for the characterization of natural and synthetic nanoparticles, but very challenging to perform using conventional mass spectrometers. Nano-electro-mechanical system (NEMS) based MS has demonstrated unique capabilities for the analysis of ultra-high mass analytes. Yet, system designs to date included constraints transferred from conventional MS instruments, such as ion guides and high vacuum requirements. Encouraged by other reports, we investigated the influence of pressure on the performances of the NEMS sensor and the aerodynamic focusing lens that equipped our first-generation instrument. We thus realized that the NEMS spectrometer could operate at significantly higher pressures than anticipated without compromising particle focusing nor mass measurement quality. Based on these observations, we designed and constructed a new NEMS-MS prototype considerably more compact than our original system, and which features an improved aerodynamic lens alignment concept, yielding superior particle focusing. We evaluated this new prototype by performing nanoparticle deposition to characterize aerodynamic focusing, and mass measurements of calibrated gold nanoparticles samples. The particle capture efficiency showed nearly two orders of magnitude improvement compared to our previous prototype, while operating at two orders of magnitude greater pressure, and without compromising mass resolution. |
| first_indexed | 2024-03-11T21:13:45Z |
| format | Article |
| id | doaj.art-5ca7ec427ea2439685402f919e44717a |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-03-11T21:13:45Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-5ca7ec427ea2439685402f919e44717a2023-09-29T06:01:55ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462023-09-011110.3389/fchem.2023.12386741238674Compact and modular system architecture for a nano-resonator-mass spectrometerAdrien Reynaud0Wioletta Trzpil1Louis Dartiguelongue2Louis Dartiguelongue3Vaitson Çumaku4Vaitson Çumaku5Thomas Fortin6Thomas Fortin7Marc Sansa8Sebastien Hentz9Christophe Masselon10Christophe Masselon11Université Grenoble Alpes, CEA-Leti, Grenoble, FranceUniversité Grenoble Alpes, CEA-Leti, Grenoble, FranceUniversité Grenoble Alpes, CEA, Institut de Recherche Interdisciplinaire de Grenoble, Grenoble, FranceINSERM UA13 Biosciences et bioingénérie pour la santé, Grenoble, FranceUniversité Grenoble Alpes, CEA, Institut de Recherche Interdisciplinaire de Grenoble, Grenoble, FranceINSERM UA13 Biosciences et bioingénérie pour la santé, Grenoble, FranceUniversité Grenoble Alpes, CEA, Institut de Recherche Interdisciplinaire de Grenoble, Grenoble, FranceINSERM UA13 Biosciences et bioingénérie pour la santé, Grenoble, FranceUniversité Grenoble Alpes, CEA-Leti, Grenoble, FranceUniversité Grenoble Alpes, CEA-Leti, Grenoble, FranceUniversité Grenoble Alpes, CEA, Institut de Recherche Interdisciplinaire de Grenoble, Grenoble, FranceINSERM UA13 Biosciences et bioingénérie pour la santé, Grenoble, FranceMass measurements in the mega-to giga-Dalton range are essential for the characterization of natural and synthetic nanoparticles, but very challenging to perform using conventional mass spectrometers. Nano-electro-mechanical system (NEMS) based MS has demonstrated unique capabilities for the analysis of ultra-high mass analytes. Yet, system designs to date included constraints transferred from conventional MS instruments, such as ion guides and high vacuum requirements. Encouraged by other reports, we investigated the influence of pressure on the performances of the NEMS sensor and the aerodynamic focusing lens that equipped our first-generation instrument. We thus realized that the NEMS spectrometer could operate at significantly higher pressures than anticipated without compromising particle focusing nor mass measurement quality. Based on these observations, we designed and constructed a new NEMS-MS prototype considerably more compact than our original system, and which features an improved aerodynamic lens alignment concept, yielding superior particle focusing. We evaluated this new prototype by performing nanoparticle deposition to characterize aerodynamic focusing, and mass measurements of calibrated gold nanoparticles samples. The particle capture efficiency showed nearly two orders of magnitude improvement compared to our previous prototype, while operating at two orders of magnitude greater pressure, and without compromising mass resolution.https://www.frontiersin.org/articles/10.3389/fchem.2023.1238674/fullmass spectrometryNEMSaerodynamic lensresonatorsingle particle |
| spellingShingle | Adrien Reynaud Wioletta Trzpil Louis Dartiguelongue Louis Dartiguelongue Vaitson Çumaku Vaitson Çumaku Thomas Fortin Thomas Fortin Marc Sansa Sebastien Hentz Christophe Masselon Christophe Masselon Compact and modular system architecture for a nano-resonator-mass spectrometer Frontiers in Chemistry mass spectrometry NEMS aerodynamic lens resonator single particle |
| title | Compact and modular system architecture for a nano-resonator-mass spectrometer |
| title_full | Compact and modular system architecture for a nano-resonator-mass spectrometer |
| title_fullStr | Compact and modular system architecture for a nano-resonator-mass spectrometer |
| title_full_unstemmed | Compact and modular system architecture for a nano-resonator-mass spectrometer |
| title_short | Compact and modular system architecture for a nano-resonator-mass spectrometer |
| title_sort | compact and modular system architecture for a nano resonator mass spectrometer |
| topic | mass spectrometry NEMS aerodynamic lens resonator single particle |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2023.1238674/full |
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