The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trials
BackgroundThe treatment of condyloma acuminatum (CA), especially the very persistent and recurrent CA, is currently the focus of our research. Immunotherapies have recently been shown to be well-tolerated and effective in treating warts, particularly refractory warts. However, there is still a lack...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1260139/full |
| _version_ | 1797405039702048768 |
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| author | Xiaoye Liu Manli Qi |
| author_facet | Xiaoye Liu Manli Qi |
| author_sort | Xiaoye Liu |
| collection | DOAJ |
| description | BackgroundThe treatment of condyloma acuminatum (CA), especially the very persistent and recurrent CA, is currently the focus of our research. Immunotherapies have recently been shown to be well-tolerated and effective in treating warts, particularly refractory warts. However, there is still a lack of corresponding evidence-based medical evidence on the effectiveness of different immunotherapies in treating warts. The difference between network meta-analysis and meta-analysis is that network meta-analysis can be used to compare multiple treatments by combining direct and indirect evidence to assess the interrelationship between all treatments. We intend to compare the efficacy of different treatments for CA using a network meta-analysis.MethodsPubMed, Cochrane Library and Embase from inception to June 1st, 2023 were searched using a computer. All articles on immunotherapies for CA were included. Stata MP17.0 software was used for data analyses.ResultsA total of 8 randomly-controlled trials involving 493 patients were included. Result showed that all treatment measures had a significant efficacy compared with the regular saline group (BCG (bacillus Calmette-Guérin vaccine) OR = 96.00, 95%CI: 10.35–890.58; MMR (measle, mumps and rubella vaccine) OR = 29.69, 95%CI: 7.47–118.04; Candida antigens OR = 27.34, 95%CI: 8.64–86.52; PPDs (purified protein derivatives) OR = 23.33, 95%CI: 6.75–80.60; VD3 OR = 21.36, 95%CI: 4.34–105.16 and purified protein derivatives (general) OR = 13.14, 95%CI: 3.38–51.12). The area under the curve (SUCRA) ranking results showed that the bacillus Calmette-Guérin vaccine had the highest total efficiency, which was 88.2%, with the rest in the order of measle, mumps and rubella vaccine, which was 68.9%, Candida antigens, which was 63.6%, purified protein derivatives, which was 52.9%, vitamin D3, which was 49.0%, purified protein derivatives (general), which was 27.4%, and saline, which was 0%.ConclusionIn summary, we found that the bacillus Calmette-Guérin vaccine was superior to other treatments in terms of efficacy according to the SUCRA value. |
| first_indexed | 2024-03-09T03:03:54Z |
| format | Article |
| id | doaj.art-5ca87002dffa492ab6ac9b59e4e01c6b |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-09T03:03:54Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-5ca87002dffa492ab6ac9b59e4e01c6b2023-12-04T08:57:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-11-011010.3389/fmed.2023.12601391260139The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trialsXiaoye LiuManli QiBackgroundThe treatment of condyloma acuminatum (CA), especially the very persistent and recurrent CA, is currently the focus of our research. Immunotherapies have recently been shown to be well-tolerated and effective in treating warts, particularly refractory warts. However, there is still a lack of corresponding evidence-based medical evidence on the effectiveness of different immunotherapies in treating warts. The difference between network meta-analysis and meta-analysis is that network meta-analysis can be used to compare multiple treatments by combining direct and indirect evidence to assess the interrelationship between all treatments. We intend to compare the efficacy of different treatments for CA using a network meta-analysis.MethodsPubMed, Cochrane Library and Embase from inception to June 1st, 2023 were searched using a computer. All articles on immunotherapies for CA were included. Stata MP17.0 software was used for data analyses.ResultsA total of 8 randomly-controlled trials involving 493 patients were included. Result showed that all treatment measures had a significant efficacy compared with the regular saline group (BCG (bacillus Calmette-Guérin vaccine) OR = 96.00, 95%CI: 10.35–890.58; MMR (measle, mumps and rubella vaccine) OR = 29.69, 95%CI: 7.47–118.04; Candida antigens OR = 27.34, 95%CI: 8.64–86.52; PPDs (purified protein derivatives) OR = 23.33, 95%CI: 6.75–80.60; VD3 OR = 21.36, 95%CI: 4.34–105.16 and purified protein derivatives (general) OR = 13.14, 95%CI: 3.38–51.12). The area under the curve (SUCRA) ranking results showed that the bacillus Calmette-Guérin vaccine had the highest total efficiency, which was 88.2%, with the rest in the order of measle, mumps and rubella vaccine, which was 68.9%, Candida antigens, which was 63.6%, purified protein derivatives, which was 52.9%, vitamin D3, which was 49.0%, purified protein derivatives (general), which was 27.4%, and saline, which was 0%.ConclusionIn summary, we found that the bacillus Calmette-Guérin vaccine was superior to other treatments in terms of efficacy according to the SUCRA value.https://www.frontiersin.org/articles/10.3389/fmed.2023.1260139/fullacuminatumHPVimmunotherapyBCGMRRCandida antigen |
| spellingShingle | Xiaoye Liu Manli Qi The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trials Frontiers in Medicine acuminatum HPV immunotherapy BCG MRR Candida antigen |
| title | The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trials |
| title_full | The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trials |
| title_fullStr | The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trials |
| title_full_unstemmed | The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trials |
| title_short | The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trials |
| title_sort | effectiveness of different immunotherapies in the treatment of condyloma acuminatum a network meta analysis of randomized clinical trials |
| topic | acuminatum HPV immunotherapy BCG MRR Candida antigen |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1260139/full |
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