Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 Levels
Although CA 19-9 is a commonly used tumor marker in the management of PBMs, the literature describing outcomes in patients with PBMs who have undetectable or low (hereinafter “low”) CA 19-9 levels remains scarce. In this study, we sought to compare clinical features and outcomes in patients with PBM...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/6/1723 |
| _version_ | 1797612986092748800 |
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| author | Jade Law Harry Trieu Guneet Kaleka Joanna Turkiewicz Samantha Palmer Jennifer M. Lee Kathryn T. Chen James H. Tabibian |
| author_facet | Jade Law Harry Trieu Guneet Kaleka Joanna Turkiewicz Samantha Palmer Jennifer M. Lee Kathryn T. Chen James H. Tabibian |
| author_sort | Jade Law |
| collection | DOAJ |
| description | Although CA 19-9 is a commonly used tumor marker in the management of PBMs, the literature describing outcomes in patients with PBMs who have undetectable or low (hereinafter “low”) CA 19-9 levels remains scarce. In this study, we sought to compare clinical features and outcomes in patients with PBMs and low CA 19-9 levels to those with normal and elevated CA 19-9 levels. Methods: We retrospectively collected data on patients with biopsy-confirmed PBMs and stratified patients into categories based on their CA 19-9 level at diagnosis. Survival curves were estimated for patients in each of the three aforementioned CA 19-9 groups using the Kaplan–Meier method and compared using a Cox proportional hazards regression model. Results: Of the 283 patients identified, 23 (8.1%) had low, 70 (24.7%) had normal, and 190 (67.1%) had elevated CA 19-9 levels. After controlling for sex, age, BMI, the presence of metastases at the time of diagnosis, and treatment with curative intent, the hazard ratio for death in the elevated CA 19-9 group compared to the low CA 19-9 group was 1.993 (95% CI 1.089–3.648; <i>p</i> = 0.025). Conclusion: The elevated CA 19-9 level compared to the low CA 19-9 level and the presence of metastases were associated with an increased hazard of death, while treatment with curative intent was associated with a decreased hazard of death. |
| first_indexed | 2024-03-11T06:48:35Z |
| format | Article |
| id | doaj.art-5ca885490dc747c2a907edefad06b22e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T06:48:35Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5ca885490dc747c2a907edefad06b22e2023-11-17T10:06:19ZengMDPI AGCancers2072-66942023-03-01156172310.3390/cancers15061723Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 LevelsJade Law0Harry Trieu1Guneet Kaleka2Joanna Turkiewicz3Samantha Palmer4Jennifer M. Lee5Kathryn T. Chen6James H. Tabibian7LAC-USC Hematology and Oncology Fellowship Program, Los Angeles, CA 90033, USALAC-USC Internal Medicine Residency Program, Los Angeles, CA 90033, USAUCLA-Olive View Internal Medicine Residency Program, Sylmar, CA 91342, USAUCLA-Olive View Internal Medicine Residency Program, Sylmar, CA 91342, USAUCLA-Olive View Internal Medicine Residency Program, Sylmar, CA 91342, USAHarbor-UCLA Medical Center, Division of Hematology and Medical Oncology, Torrance, CA 90502, USAHarbor-UCLA Medical Center, Division of Surgical Oncology, Torrance, CA 90502, USAUCLA-Olive View, Division of Gastroenterology, Sylmar, CA 91342, USAAlthough CA 19-9 is a commonly used tumor marker in the management of PBMs, the literature describing outcomes in patients with PBMs who have undetectable or low (hereinafter “low”) CA 19-9 levels remains scarce. In this study, we sought to compare clinical features and outcomes in patients with PBMs and low CA 19-9 levels to those with normal and elevated CA 19-9 levels. Methods: We retrospectively collected data on patients with biopsy-confirmed PBMs and stratified patients into categories based on their CA 19-9 level at diagnosis. Survival curves were estimated for patients in each of the three aforementioned CA 19-9 groups using the Kaplan–Meier method and compared using a Cox proportional hazards regression model. Results: Of the 283 patients identified, 23 (8.1%) had low, 70 (24.7%) had normal, and 190 (67.1%) had elevated CA 19-9 levels. After controlling for sex, age, BMI, the presence of metastases at the time of diagnosis, and treatment with curative intent, the hazard ratio for death in the elevated CA 19-9 group compared to the low CA 19-9 group was 1.993 (95% CI 1.089–3.648; <i>p</i> = 0.025). Conclusion: The elevated CA 19-9 level compared to the low CA 19-9 level and the presence of metastases were associated with an increased hazard of death, while treatment with curative intent was associated with a decreased hazard of death.https://www.mdpi.com/2072-6694/15/6/1723early detection of cancerbiomarkersadenocarcinomapancreatic carcinoma |
| spellingShingle | Jade Law Harry Trieu Guneet Kaleka Joanna Turkiewicz Samantha Palmer Jennifer M. Lee Kathryn T. Chen James H. Tabibian Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 Levels Cancers early detection of cancer biomarkers adenocarcinoma pancreatic carcinoma |
| title | Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 Levels |
| title_full | Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 Levels |
| title_fullStr | Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 Levels |
| title_full_unstemmed | Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 Levels |
| title_short | Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 Levels |
| title_sort | clinical features and outcomes of patients with pancreaticobiliary malignancies in los angeles county and their association with ca 19 9 levels |
| topic | early detection of cancer biomarkers adenocarcinoma pancreatic carcinoma |
| url | https://www.mdpi.com/2072-6694/15/6/1723 |
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