Serum-Mediated Oxidative Stress from Systemic Sclerosis Patients Affects Mesenchymal Stem Cell Function

Serum-Mediated Oxidative Stress from Systemic Sclerosis Patients Affects Mesenchymal Stem Cell Function

ObjectivesProperties of mesenchymal stromal/stem cells (MSCs) from systemic sclerosis (SSc) patients have been reported to be altered. MSC-based therapy may therefore rely on the use of allogeneic MSCs from healthy subjects. Here, we investigated whether heterologous MSCs could exhibit altered prope...

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Bibliographic Details
Main Authors: Guillaume Fonteneau, Claire Bony, Radjiv Goulabchand, Alexandre T. J. Maria, Alain Le Quellec, Sophie Rivière, Christian Jorgensen, Philippe Guilpain, Danièle Noël
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stem cells
systemic sclerosis
cell therapy
oxidative stress
advanced oxidation protein product
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00988/full

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