Activation of the microglial P2X7R/NLRP3 inflammasome mediates central sensitization in a mouse model of medication overuse headache

Activation of the microglial P2X7R/NLRP3 inflammasome mediates central sensitization in a mouse model of medication overuse headache

BackgroundExcessive use of headache treatments often leads to the development, progression and exacerbation of primary headache, which is defined as medication overuse headache (MOH). A significant pathophysiological mechanism of MOH is central sensitization. Recent evidence suggests that central se...

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Bibliographic Details
Main Authors: Yanyun Wang, Liang Dong, Yun Zhang, Yixin Zhang, Guangcheng Qin, Dunke Zhang, Lixue Chen, Wei He, Jiying Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
microglia
medication overuse headache
central sensitization
P2X7R
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1177171/full

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