Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach
It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/2/1622/ |
| _version_ | 1797708260016390144 |
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| author | Timothy A. Rockall Christopher G. Marks Myutan Kulendran John F. Stebbing |
| author_facet | Timothy A. Rockall Christopher G. Marks Myutan Kulendran John F. Stebbing |
| author_sort | Timothy A. Rockall |
| collection | DOAJ |
| description | It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β. |
| first_indexed | 2024-03-12T06:18:42Z |
| format | Article |
| id | doaj.art-5cad1f880b4a4a53b005c68f02f1e8d3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:18:42Z |
| publishDate | 2011-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5cad1f880b4a4a53b005c68f02f1e8d32023-09-03T02:20:57ZengMDPI AGCancers2072-66942011-03-01321622163810.3390/cancers3021622Predictive and Prognostic Factors in Colorectal Cancer: A Personalized ApproachTimothy A. RockallChristopher G. MarksMyutan KulendranJohn F. StebbingIt is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β.http://www.mdpi.com/2072-6694/3/2/1622/predictive and prognostic factorscolorectal cancerpersonalized medicineAPCMSIMMRKRASBRAF18qLOHCIMPTGF-βCINMGMTTP53FOBTvimentincirculating tumor cells |
| spellingShingle | Timothy A. Rockall Christopher G. Marks Myutan Kulendran John F. Stebbing Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach Cancers predictive and prognostic factors colorectal cancer personalized medicine APC MSI MMR KRAS BRAF 18qLOH CIMP TGF-β CIN MGMT TP53 FOBT vimentin circulating tumor cells |
| title | Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach |
| title_full | Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach |
| title_fullStr | Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach |
| title_full_unstemmed | Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach |
| title_short | Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach |
| title_sort | predictive and prognostic factors in colorectal cancer a personalized approach |
| topic | predictive and prognostic factors colorectal cancer personalized medicine APC MSI MMR KRAS BRAF 18qLOH CIMP TGF-β CIN MGMT TP53 FOBT vimentin circulating tumor cells |
| url | http://www.mdpi.com/2072-6694/3/2/1622/ |
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