From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease
Aberrant behavior and function of neurons are believed to be the primary causes of most neurological diseases and psychiatric disorders. Human postmortem samples have limited availability and, while they provide clues to the state of the brain after a prolonged illness, they offer limited insight in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-01-01
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| Series: | Biomarker Insights |
| Online Access: | https://doi.org/10.4137/BMI.S20066 |
| _version_ | 1818145667809280000 |
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| author | Seok-Man Ho Aaron Topol Kristen J. Brennand |
| author_facet | Seok-Man Ho Aaron Topol Kristen J. Brennand |
| author_sort | Seok-Man Ho |
| collection | DOAJ |
| description | Aberrant behavior and function of neurons are believed to be the primary causes of most neurological diseases and psychiatric disorders. Human postmortem samples have limited availability and, while they provide clues to the state of the brain after a prolonged illness, they offer limited insight into the factors contributing to disease onset. Conversely, animal models cannot recapitulate the polygenic origins of neuropsychiatric disease. Novel methods, such as somatic cell reprogramming, deliver nearly limitless numbers of pathogenic human neurons for the study of the mechanism of neuropsychiatric disease initiation and progression. First, this article reviews the advent of human induced pluripotent stem cell (hiPSC) technology and introduces two major methods, “directed differentiation” and “neuronal induction,” by which it is now possible to generate neurons for modeling neuropsychiatric disease. Second, it discusses the recent applications, and the limitations, of these technologies to in vitro studies of psychiatric disorders. |
| first_indexed | 2024-12-11T12:07:06Z |
| format | Article |
| id | doaj.art-5cb00c9dfb624feaba9954ea4b220798 |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-11T12:07:06Z |
| publishDate | 2015-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-5cb00c9dfb624feaba9954ea4b2207982022-12-22T01:07:54ZengSAGE PublishingBiomarker Insights1177-27192015-01-0110s110.4137/BMI.S20066From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric DiseaseSeok-Man Ho0Aaron Topol1Kristen J. Brennand2Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA.Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA.Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA.Aberrant behavior and function of neurons are believed to be the primary causes of most neurological diseases and psychiatric disorders. Human postmortem samples have limited availability and, while they provide clues to the state of the brain after a prolonged illness, they offer limited insight into the factors contributing to disease onset. Conversely, animal models cannot recapitulate the polygenic origins of neuropsychiatric disease. Novel methods, such as somatic cell reprogramming, deliver nearly limitless numbers of pathogenic human neurons for the study of the mechanism of neuropsychiatric disease initiation and progression. First, this article reviews the advent of human induced pluripotent stem cell (hiPSC) technology and introduces two major methods, “directed differentiation” and “neuronal induction,” by which it is now possible to generate neurons for modeling neuropsychiatric disease. Second, it discusses the recent applications, and the limitations, of these technologies to in vitro studies of psychiatric disorders.https://doi.org/10.4137/BMI.S20066 |
| spellingShingle | Seok-Man Ho Aaron Topol Kristen J. Brennand From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease Biomarker Insights |
| title | From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease |
| title_full | From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease |
| title_fullStr | From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease |
| title_full_unstemmed | From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease |
| title_short | From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease |
| title_sort | from directed differentiation to neuronal induction modeling neuropsychiatric disease |
| url | https://doi.org/10.4137/BMI.S20066 |
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