Genesis and Mechanism of Some Cancer Types and an Overview on the Role of Diet and Nutrition in Cancer Prevention
Cancer is a major disease with a high mortality rate worldwide. In many countries, cancer is considered to be the second most common cause of death after cardiovascular disease. The clinical management of cancer continues to be a challenge as conventional treatments, such as chemotherapy and radiati...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/6/1794 |
| _version_ | 1797444433835196416 |
|---|---|
| author | Nurkhalida Kamal Muna Abdulsalam Ilowefah Ayah Rebhi Hilles Nurul Adlina Anua Tahani Awin Hussah Abdullah Alshwyeh Sahar Khamees Aldosary Najla Gooda Sahib Jambocus Areej A. Alosaimi Azizur Rahman Syed Mahmood Ahmed Mediani |
| author_facet | Nurkhalida Kamal Muna Abdulsalam Ilowefah Ayah Rebhi Hilles Nurul Adlina Anua Tahani Awin Hussah Abdullah Alshwyeh Sahar Khamees Aldosary Najla Gooda Sahib Jambocus Areej A. Alosaimi Azizur Rahman Syed Mahmood Ahmed Mediani |
| author_sort | Nurkhalida Kamal |
| collection | DOAJ |
| description | Cancer is a major disease with a high mortality rate worldwide. In many countries, cancer is considered to be the second most common cause of death after cardiovascular disease. The clinical management of cancer continues to be a challenge as conventional treatments, such as chemotherapy and radiation therapy, have limitations due to their toxicity profiles. Unhealthy lifestyle and poor dietary habits are the key risk factors for cancer; having a healthy diet and lifestyle may minimize the risk. Epidemiological studies have shown that a high fruit and vegetable intake in our regular diet can effectively reduce the risk of developing certain types of cancers due to the high contents of antioxidants and phytochemicals. In vitro and in vivo studies have shown that phytochemicals exert significant anticancer effects due to their free radical scavenging capacity potential. There has been extensive research on the protective effects of phytochemicals in different types of cancers. This review attempts to give an overview of the etiology of different types of cancers and assesses the role of phytonutrients in the prevention of cancers, which makes the present review distinct from the others available. |
| first_indexed | 2024-03-09T13:11:33Z |
| format | Article |
| id | doaj.art-5cb148fc080a4d8bb4c2953f8c210760 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T13:11:33Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5cb148fc080a4d8bb4c2953f8c2107602023-11-30T21:41:16ZengMDPI AGMolecules1420-30492022-03-01276179410.3390/molecules27061794Genesis and Mechanism of Some Cancer Types and an Overview on the Role of Diet and Nutrition in Cancer PreventionNurkhalida Kamal0Muna Abdulsalam Ilowefah1Ayah Rebhi Hilles2Nurul Adlina Anua3Tahani Awin4Hussah Abdullah Alshwyeh5Sahar Khamees Aldosary6Najla Gooda Sahib Jambocus7Areej A. Alosaimi8Azizur Rahman9Syed Mahmood10Ahmed Mediani11Institute of Systems Biology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, MalaysiaDepartment of Food Technology, Faculty of Engineering and Technology, Sabha University, Sabha 00218, LibyaInstitute for Halal Research and Training (INHART), International Islamic University Malaysia, Kuala Lumpur 53100, MalaysiaInstitute of Systems Biology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, MalaysiaDepartment of Chemistry, Faculty of Science, University of Benghazi, Qar Yunis, Benghazi 5341, LibyaDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi ArabiaDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi ArabiaMinistry of Education, Tertiary Education, Science and Technology, MITD House, Phoenix 73544, MauritiusDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi ArabiaDepartment of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, MalaysiaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, MalaysiaInstitute of Systems Biology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, MalaysiaCancer is a major disease with a high mortality rate worldwide. In many countries, cancer is considered to be the second most common cause of death after cardiovascular disease. The clinical management of cancer continues to be a challenge as conventional treatments, such as chemotherapy and radiation therapy, have limitations due to their toxicity profiles. Unhealthy lifestyle and poor dietary habits are the key risk factors for cancer; having a healthy diet and lifestyle may minimize the risk. Epidemiological studies have shown that a high fruit and vegetable intake in our regular diet can effectively reduce the risk of developing certain types of cancers due to the high contents of antioxidants and phytochemicals. In vitro and in vivo studies have shown that phytochemicals exert significant anticancer effects due to their free radical scavenging capacity potential. There has been extensive research on the protective effects of phytochemicals in different types of cancers. This review attempts to give an overview of the etiology of different types of cancers and assesses the role of phytonutrients in the prevention of cancers, which makes the present review distinct from the others available.https://www.mdpi.com/1420-3049/27/6/1794cancerdiagnosisdietnutritionphytochemicalstherapeutics |
| spellingShingle | Nurkhalida Kamal Muna Abdulsalam Ilowefah Ayah Rebhi Hilles Nurul Adlina Anua Tahani Awin Hussah Abdullah Alshwyeh Sahar Khamees Aldosary Najla Gooda Sahib Jambocus Areej A. Alosaimi Azizur Rahman Syed Mahmood Ahmed Mediani Genesis and Mechanism of Some Cancer Types and an Overview on the Role of Diet and Nutrition in Cancer Prevention Molecules cancer diagnosis diet nutrition phytochemicals therapeutics |
| title | Genesis and Mechanism of Some Cancer Types and an Overview on the Role of Diet and Nutrition in Cancer Prevention |
| title_full | Genesis and Mechanism of Some Cancer Types and an Overview on the Role of Diet and Nutrition in Cancer Prevention |
| title_fullStr | Genesis and Mechanism of Some Cancer Types and an Overview on the Role of Diet and Nutrition in Cancer Prevention |
| title_full_unstemmed | Genesis and Mechanism of Some Cancer Types and an Overview on the Role of Diet and Nutrition in Cancer Prevention |
| title_short | Genesis and Mechanism of Some Cancer Types and an Overview on the Role of Diet and Nutrition in Cancer Prevention |
| title_sort | genesis and mechanism of some cancer types and an overview on the role of diet and nutrition in cancer prevention |
| topic | cancer diagnosis diet nutrition phytochemicals therapeutics |
| url | https://www.mdpi.com/1420-3049/27/6/1794 |
| work_keys_str_mv | AT nurkhalidakamal genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT munaabdulsalamilowefah genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT ayahrebhihilles genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT nuruladlinaanua genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT tahaniawin genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT hussahabdullahalshwyeh genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT saharkhameesaldosary genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT najlagoodasahibjambocus genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT areejaalosaimi genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT azizurrahman genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT syedmahmood genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention AT ahmedmediani genesisandmechanismofsomecancertypesandanoverviewontheroleofdietandnutritionincancerprevention |