Potential anti-Alzheimer’s disease effect of defatted walnut powder through remodeling gut microbiota and modulating amino acid metabolite levels
Alzheimer’s disease (AD) is a major health challenge due to its high morbidity. This study aimed to investigate the potential effects of defatted walnut powder (DWP), which is the residue obtained after extracting oil from walnut kernels, on memory improvement. HPLC was used to establish the fingerp...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623004917 |
| _version_ | 1797435801373507584 |
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| author | Xiajing Xu Yong Ding Xuanmeng Zhang Meihan Liu Dongmei Wang Yingni Pan Shumeng Ren Xiaoqiu Liu |
| author_facet | Xiajing Xu Yong Ding Xuanmeng Zhang Meihan Liu Dongmei Wang Yingni Pan Shumeng Ren Xiaoqiu Liu |
| author_sort | Xiajing Xu |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a major health challenge due to its high morbidity. This study aimed to investigate the potential effects of defatted walnut powder (DWP), which is the residue obtained after extracting oil from walnut kernels, on memory improvement. HPLC was used to establish the fingerprints of 14 batches of DWP extract (DWPE) obtained from various origins. Behavioral experiments and functional indicators were conducted to evaluate the efficacy of DWPE on AD. The results indicated that DWPE regulated the cholinergic system disorder in brain tissue. Additionally, DWPE reduced oxidative stress levels, neuroinflammation, and the damage of pyramidal cells in both the cortex and the hippocampal CA3 region. Subsequently, targeted amino acid metabolomics, gut microbiota sequencing and fecal microbiota transplantation confirmed that DWPE played a regulatory role in amino acid metabolism regulated by gut microbiota, effectively decreasing the levels of fat-soluble neurotoxic factor ammonia. |
| first_indexed | 2024-03-09T10:53:20Z |
| format | Article |
| id | doaj.art-5cb1b5c6ef87469e927f42d464b929a2 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-09T10:53:20Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-5cb1b5c6ef87469e927f42d464b929a22023-12-01T05:01:12ZengElsevierJournal of Functional Foods1756-46462023-12-01111105891Potential anti-Alzheimer’s disease effect of defatted walnut powder through remodeling gut microbiota and modulating amino acid metabolite levelsXiajing Xu0Yong Ding1Xuanmeng Zhang2Meihan Liu3Dongmei Wang4Yingni Pan5Shumeng Ren6Xiaoqiu Liu7School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang District, Shenyang, Liaoning 110016, PR ChinaSchool of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang District, Shenyang, Liaoning 110016, PR ChinaSchool of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang District, Shenyang, Liaoning 110016, PR ChinaSchool of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang District, Shenyang, Liaoning 110016, PR ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang District, Shenyang, Liaoning 110016, PR ChinaSchool of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang District, Shenyang, Liaoning 110016, PR ChinaSchool of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang District, Shenyang, Liaoning 110016, PR China; Corresponding author.School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang District, Shenyang, Liaoning 110016, PR China; Corresponding author.Alzheimer’s disease (AD) is a major health challenge due to its high morbidity. This study aimed to investigate the potential effects of defatted walnut powder (DWP), which is the residue obtained after extracting oil from walnut kernels, on memory improvement. HPLC was used to establish the fingerprints of 14 batches of DWP extract (DWPE) obtained from various origins. Behavioral experiments and functional indicators were conducted to evaluate the efficacy of DWPE on AD. The results indicated that DWPE regulated the cholinergic system disorder in brain tissue. Additionally, DWPE reduced oxidative stress levels, neuroinflammation, and the damage of pyramidal cells in both the cortex and the hippocampal CA3 region. Subsequently, targeted amino acid metabolomics, gut microbiota sequencing and fecal microbiota transplantation confirmed that DWPE played a regulatory role in amino acid metabolism regulated by gut microbiota, effectively decreasing the levels of fat-soluble neurotoxic factor ammonia.http://www.sciencedirect.com/science/article/pii/S1756464623004917Defatted walnut powderAlzheimer’s diseaseGut microbiotaAmino acid metabolismAmmonia |
| spellingShingle | Xiajing Xu Yong Ding Xuanmeng Zhang Meihan Liu Dongmei Wang Yingni Pan Shumeng Ren Xiaoqiu Liu Potential anti-Alzheimer’s disease effect of defatted walnut powder through remodeling gut microbiota and modulating amino acid metabolite levels Journal of Functional Foods Defatted walnut powder Alzheimer’s disease Gut microbiota Amino acid metabolism Ammonia |
| title | Potential anti-Alzheimer’s disease effect of defatted walnut powder through remodeling gut microbiota and modulating amino acid metabolite levels |
| title_full | Potential anti-Alzheimer’s disease effect of defatted walnut powder through remodeling gut microbiota and modulating amino acid metabolite levels |
| title_fullStr | Potential anti-Alzheimer’s disease effect of defatted walnut powder through remodeling gut microbiota and modulating amino acid metabolite levels |
| title_full_unstemmed | Potential anti-Alzheimer’s disease effect of defatted walnut powder through remodeling gut microbiota and modulating amino acid metabolite levels |
| title_short | Potential anti-Alzheimer’s disease effect of defatted walnut powder through remodeling gut microbiota and modulating amino acid metabolite levels |
| title_sort | potential anti alzheimer s disease effect of defatted walnut powder through remodeling gut microbiota and modulating amino acid metabolite levels |
| topic | Defatted walnut powder Alzheimer’s disease Gut microbiota Amino acid metabolism Ammonia |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623004917 |
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