Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report
Multifocal brain abscesses caused by invasive Streptococcus intermedia are relatively rare. Here, we present a 67-year-old male was admitted to the hospital for unconsciousness and fever. The computed tomography (CT) examination showed multiple intracranial space-occupying and “cavity-like” changes...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.893627/full |
| _version_ | 1811216303127527424 |
|---|---|
| author | Lin Yao Sansong Chen Zuan Yu Tao Yu |
| author_facet | Lin Yao Sansong Chen Zuan Yu Tao Yu |
| author_sort | Lin Yao |
| collection | DOAJ |
| description | Multifocal brain abscesses caused by invasive Streptococcus intermedia are relatively rare. Here, we present a 67-year-old male was admitted to the hospital for unconsciousness and fever. The computed tomography (CT) examination showed multiple intracranial space-occupying and “cavity-like” changes in the right lower lung. The examination of cerebrospinal fluid (CSF) was consistent with typical bacterial meningitis, CSF analyses revealed leukocytosis (10,300 × 106/L), elevated protein levels (140.39 mg/dL), decreased glucose levels (0.27 mmol/L), and normal chloride concentration level (120.2 mmol/L), however, pathogens were not detected in the cultures. Then, the CSF and sputum samples were analyzed using meta-genomic next-generation sequencing (mNGS), and S. intermedia was detected in both samples. We adjusted the use of antibiotics according to the results of mNGS in time. After anti-infective treatment, the patient achieved good treatment results in a very short time. This case highlights the mNGS can identify pathogens of brain abscess, and provide strong evidence for clinical diagnosis and treatment strategy. |
| first_indexed | 2024-04-12T06:36:54Z |
| format | Article |
| id | doaj.art-5cb1ff29bf15432cbb109f3dc4d54c24 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T06:36:54Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-5cb1ff29bf15432cbb109f3dc4d54c242022-12-22T03:43:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-08-011310.3389/fneur.2022.893627893627Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case reportLin YaoSansong ChenZuan YuTao YuMultifocal brain abscesses caused by invasive Streptococcus intermedia are relatively rare. Here, we present a 67-year-old male was admitted to the hospital for unconsciousness and fever. The computed tomography (CT) examination showed multiple intracranial space-occupying and “cavity-like” changes in the right lower lung. The examination of cerebrospinal fluid (CSF) was consistent with typical bacterial meningitis, CSF analyses revealed leukocytosis (10,300 × 106/L), elevated protein levels (140.39 mg/dL), decreased glucose levels (0.27 mmol/L), and normal chloride concentration level (120.2 mmol/L), however, pathogens were not detected in the cultures. Then, the CSF and sputum samples were analyzed using meta-genomic next-generation sequencing (mNGS), and S. intermedia was detected in both samples. We adjusted the use of antibiotics according to the results of mNGS in time. After anti-infective treatment, the patient achieved good treatment results in a very short time. This case highlights the mNGS can identify pathogens of brain abscess, and provide strong evidence for clinical diagnosis and treatment strategy.https://www.frontiersin.org/articles/10.3389/fneur.2022.893627/fullmultiple brain abscessesStreptococcus intermediameta-genomic next-generation sequencingcase reportcerebrospinal fluid |
| spellingShingle | Lin Yao Sansong Chen Zuan Yu Tao Yu Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report Frontiers in Neurology multiple brain abscesses Streptococcus intermedia meta-genomic next-generation sequencing case report cerebrospinal fluid |
| title | Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report |
| title_full | Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report |
| title_fullStr | Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report |
| title_full_unstemmed | Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report |
| title_short | Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report |
| title_sort | multifocal brain abscesses caused by invasive streptococcus intermedia a case report |
| topic | multiple brain abscesses Streptococcus intermedia meta-genomic next-generation sequencing case report cerebrospinal fluid |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.893627/full |
| work_keys_str_mv | AT linyao multifocalbrainabscessescausedbyinvasivestreptococcusintermediaacasereport AT sansongchen multifocalbrainabscessescausedbyinvasivestreptococcusintermediaacasereport AT zuanyu multifocalbrainabscessescausedbyinvasivestreptococcusintermediaacasereport AT taoyu multifocalbrainabscessescausedbyinvasivestreptococcusintermediaacasereport |