Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model

Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model

Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current concept of targeting NOTCH is based on using gamma secretase inhibitors (GSI) to regulate the release of the active NOTCH intracellular domain. However, the clinical outcome of GSI remains unsatisfactor...

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Bibliographic Details
Main Authors: Rainer Hubmann, Wolfgang Sieghart, Susanne Schnabl, Mohammad Araghi, Martin Hilgarth, Marlies Reiter, Dita Demirtas, Peter Valent, Christoph Zielinski, Ulrich Jäger, Medhat Shehata
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Pharmacology
Subjects:
NOTCH2
gliotoxin
γ-secretase inhibitors
melanoma
hepatocellular carcinoma
pancreas carcinoma
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00319/full

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