The emerging roles of SUMOylation in pulmonary diseases
Abstract Small ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair, transcriptional regulation, protein stability, and cell cycle progression. Perturbation...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10020-023-00719-1 |
| _version_ | 1797452234892509184 |
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| author | Xuyang Zheng Lingqiao Wang Zhen Zhang Huifang Tang |
| author_facet | Xuyang Zheng Lingqiao Wang Zhen Zhang Huifang Tang |
| author_sort | Xuyang Zheng |
| collection | DOAJ |
| description | Abstract Small ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair, transcriptional regulation, protein stability, and cell cycle progression. Perturbation or deregulation of a SUMOylation and deSUMOylation status has emerged as a new pathophysiological feature of lung diseases. In this review, we highlighted the link between SUMO pathway and lung diseases, especially the sumoylated substrate such as C/EBPα in bronchopulmonary dysplasia (BDP), PPARγ in pneumonia, TFII-I in asthma, HDAC2 in chronic obstructive pulmonary disease (COPD), KLF15 in hypoxic pulmonary hypertension (HPH), SMAD3 in idiopathic pulmonary fibrosis (IPF), and YTHDF2 in cancer. By exploring the impact of SUMOylation in pulmonary diseases, we intend to shed light on its potential to inspire the development of innovative diagnostic and therapeutic strategies, holding promise for improving patient outcomes and overall respiratory health. |
| first_indexed | 2024-03-09T15:05:51Z |
| format | Article |
| id | doaj.art-5cb281c9e84f4b9ab3d4241ab132ab68 |
| institution | Directory Open Access Journal |
| issn | 1528-3658 |
| language | English |
| last_indexed | 2024-03-09T15:05:51Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-5cb281c9e84f4b9ab3d4241ab132ab682023-11-26T13:39:32ZengBMCMolecular Medicine1528-36582023-09-0129111210.1186/s10020-023-00719-1The emerging roles of SUMOylation in pulmonary diseasesXuyang Zheng0Lingqiao Wang1Zhen Zhang2Huifang Tang3Department of pediatrics, The Affiliated Hangzhou First People’s Hospital, Zhejiang University School of MedicineDepartment of pediatrics, The Affiliated Hangzhou First People’s Hospital, Zhejiang University School of MedicineDepartment of Orthopedics Surgery, The Affiliated Hangzhou First People’s Hospital, Zhejiang University School of MedicineDepartment of Pharmacology, Zhejiang Respiratory Drugs Research Laboratory, School of Basic Medicial Sciences, Zhejiang UniversityAbstract Small ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair, transcriptional regulation, protein stability, and cell cycle progression. Perturbation or deregulation of a SUMOylation and deSUMOylation status has emerged as a new pathophysiological feature of lung diseases. In this review, we highlighted the link between SUMO pathway and lung diseases, especially the sumoylated substrate such as C/EBPα in bronchopulmonary dysplasia (BDP), PPARγ in pneumonia, TFII-I in asthma, HDAC2 in chronic obstructive pulmonary disease (COPD), KLF15 in hypoxic pulmonary hypertension (HPH), SMAD3 in idiopathic pulmonary fibrosis (IPF), and YTHDF2 in cancer. By exploring the impact of SUMOylation in pulmonary diseases, we intend to shed light on its potential to inspire the development of innovative diagnostic and therapeutic strategies, holding promise for improving patient outcomes and overall respiratory health.https://doi.org/10.1186/s10020-023-00719-1SUMOylationPneumoniacancerHypoxic pulmonary hypertensionIdiopathic pulmonary fibrosis |
| spellingShingle | Xuyang Zheng Lingqiao Wang Zhen Zhang Huifang Tang The emerging roles of SUMOylation in pulmonary diseases Molecular Medicine SUMOylation Pneumonia cancer Hypoxic pulmonary hypertension Idiopathic pulmonary fibrosis |
| title | The emerging roles of SUMOylation in pulmonary diseases |
| title_full | The emerging roles of SUMOylation in pulmonary diseases |
| title_fullStr | The emerging roles of SUMOylation in pulmonary diseases |
| title_full_unstemmed | The emerging roles of SUMOylation in pulmonary diseases |
| title_short | The emerging roles of SUMOylation in pulmonary diseases |
| title_sort | emerging roles of sumoylation in pulmonary diseases |
| topic | SUMOylation Pneumonia cancer Hypoxic pulmonary hypertension Idiopathic pulmonary fibrosis |
| url | https://doi.org/10.1186/s10020-023-00719-1 |
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