Mitochondrial calcium regulation during and following contractions in skeletal muscle
In skeletal muscle, resting cytosolic Ca2+ concentration ([Ca2+]cyto) homeostasis is exquisitely regulated by Ca2+ transport across the sarcolemmal, mitochondrial and sarcoplasmic reticulum (SR) membranes. Specifically, skeletal muscle contractile function is critically dependent on effective SR Ca2...
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| Format: | Article |
| Language: | English |
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Japanese Society of Physical Fitness and Sports Medicine
2018-07-01
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| Series: | Journal of Physical Fitness and Sports Medicine |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpfsm/7/4/7_205/_pdf/-char/en |
| _version_ | 1819139792405790720 |
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| author | Hiroaki Eshima David C Poole Yutaka Kano |
| author_facet | Hiroaki Eshima David C Poole Yutaka Kano |
| author_sort | Hiroaki Eshima |
| collection | DOAJ |
| description | In skeletal muscle, resting cytosolic Ca2+ concentration ([Ca2+]cyto) homeostasis is exquisitely regulated by Ca2+ transport across the sarcolemmal, mitochondrial and sarcoplasmic reticulum (SR) membranes. Specifically, skeletal muscle contractile function is critically dependent on effective SR Ca2+ handling. However, more recent studies have revealed that mitochondria are essentially involved in [Ca2+]cyto homeostasis during and following muscle contractions. We recently provided substantial support for the mitochondria as a major site for Ca2+ sequestration in skeletal muscle during recovery from fatiguing tetanic contractions under in vivo conditions. This review provides an overview of the role of skeletal muscle mitochondria in [Ca2+]cyto regulation in vivo during and following muscle contractions. |
| first_indexed | 2024-12-22T11:28:17Z |
| format | Article |
| id | doaj.art-5cb3e60767424a999d1c3725bbde0454 |
| institution | Directory Open Access Journal |
| issn | 2186-8131 2186-8123 |
| language | English |
| last_indexed | 2024-12-22T11:28:17Z |
| publishDate | 2018-07-01 |
| publisher | Japanese Society of Physical Fitness and Sports Medicine |
| record_format | Article |
| series | Journal of Physical Fitness and Sports Medicine |
| spelling | doaj.art-5cb3e60767424a999d1c3725bbde04542022-12-21T18:27:41ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232018-07-017420521110.7600/jpfsm.7.205jpfsmMitochondrial calcium regulation during and following contractions in skeletal muscleHiroaki Eshima0David C Poole1Yutaka Kano2Department of Nutrition and Integrative Physiology, University of Utah School of MedicineDepartments of Anatomy & Physiology and Kinesiology, Kansas State UniversityDepartment of Engineering Science, Bioscience and Technology Program, The University of Electro-CommunicationsIn skeletal muscle, resting cytosolic Ca2+ concentration ([Ca2+]cyto) homeostasis is exquisitely regulated by Ca2+ transport across the sarcolemmal, mitochondrial and sarcoplasmic reticulum (SR) membranes. Specifically, skeletal muscle contractile function is critically dependent on effective SR Ca2+ handling. However, more recent studies have revealed that mitochondria are essentially involved in [Ca2+]cyto homeostasis during and following muscle contractions. We recently provided substantial support for the mitochondria as a major site for Ca2+ sequestration in skeletal muscle during recovery from fatiguing tetanic contractions under in vivo conditions. This review provides an overview of the role of skeletal muscle mitochondria in [Ca2+]cyto regulation in vivo during and following muscle contractions.https://www.jstage.jst.go.jp/article/jpfsm/7/4/7_205/_pdf/-char/enmitochondrial calcium homeostasisskeletal musclecontractionmitochondrial calcium uniporter (mcu) |
| spellingShingle | Hiroaki Eshima David C Poole Yutaka Kano Mitochondrial calcium regulation during and following contractions in skeletal muscle Journal of Physical Fitness and Sports Medicine mitochondrial calcium homeostasis skeletal muscle contraction mitochondrial calcium uniporter (mcu) |
| title | Mitochondrial calcium regulation during and following contractions in skeletal muscle |
| title_full | Mitochondrial calcium regulation during and following contractions in skeletal muscle |
| title_fullStr | Mitochondrial calcium regulation during and following contractions in skeletal muscle |
| title_full_unstemmed | Mitochondrial calcium regulation during and following contractions in skeletal muscle |
| title_short | Mitochondrial calcium regulation during and following contractions in skeletal muscle |
| title_sort | mitochondrial calcium regulation during and following contractions in skeletal muscle |
| topic | mitochondrial calcium homeostasis skeletal muscle contraction mitochondrial calcium uniporter (mcu) |
| url | https://www.jstage.jst.go.jp/article/jpfsm/7/4/7_205/_pdf/-char/en |
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