Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis.

Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis.

OBJECTIVES: Oxidative stress plays an important role in the pathogenesis of multiple sclerosis (MS). Though reactive oxygen species (ROS) are produced by various mechanisms, xanthine oxidase (XO) is a major enzyme generating ROS in the context of inflammation. The objectives of this study were to in...

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Main Authors: Josephe Archie Honorat, Makoto Kinoshita, Tatsusada Okuno, Kazushiro Takata, Toru Koda, Satoru Tada, Takashi Shirakura, Harutoshi Fujimura, Hideki Mochizuki, Saburo Sakoda, Yuji Nakatsuji
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3738596?pdf=render

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