A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice
The effect of krill powder, a mixed source of protein and n-3 polyunsaturated fatty acids from Antarctic krill (Euphausia superba), on hepatic gene expression was analyzed in CBA/J mice. Mice were fed a low-fat control diet or a 3% (w/w) krill powder low-fat diet for 3 months. Gene expression profil...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464613002570 |
| _version_ | 1819293729293336576 |
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| author | Bodil Bjørndal Kjetil Berge Jamie L. Barger Rolf K. Berge Lena Burri |
| author_facet | Bodil Bjørndal Kjetil Berge Jamie L. Barger Rolf K. Berge Lena Burri |
| author_sort | Bodil Bjørndal |
| collection | DOAJ |
| description | The effect of krill powder, a mixed source of protein and n-3 polyunsaturated fatty acids from Antarctic krill (Euphausia superba), on hepatic gene expression was analyzed in CBA/J mice. Mice were fed a low-fat control diet or a 3% (w/w) krill powder low-fat diet for 3 months. Gene expression profiling on liver samples revealed that the krill powder supplemented diet modulated a large number of pathways compared to the control diet. Metabolic pathways that were down-regulated included β-oxidation, glucose metabolism, and amino acid catabolism. In contrast, the mitochondrial electron transport chain pathway was upregulated. Krill powder affected more pathways involved in protein metabolism than krill oil. Thus, a krill powder supplemented diet had potent and specific effects on energy metabolism and oxidative phosphorylation at the gene level. This indicates that krill powder supplementation could be an approach to prevent decline in mitochondrial respiratory chain function. |
| first_indexed | 2024-12-24T04:15:03Z |
| format | Article |
| id | doaj.art-5cb636b398e14175baaecdd0f7e3a25b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T04:15:03Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-5cb636b398e14175baaecdd0f7e3a25b2022-12-21T17:15:57ZengElsevierJournal of Functional Foods1756-46462014-01-016623630A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in miceBodil Bjørndal0Kjetil Berge1Jamie L. Barger2Rolf K. Berge3Lena Burri4Department of Clinical Science, University of Bergen, N-5020 Bergen, NorwayAker BioMarine ASA, Fjordalléen 16, N-0115 Oslo, Oslo, NorwayLifeGen Technologies, LLC, 510 Charmany Drive, Madison, WI 53719, USADepartment of Clinical Science, University of Bergen, N-5020 Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, N-5021 Bergen, NorwayAker BioMarine ASA, Fjordalléen 16, N-0115 Oslo, Oslo, Norway; Corresponding author at: Aker BioMarine ASA, Fjordalléen 16, N-0115 Oslo, Norway. Tel.: +47 41399773.The effect of krill powder, a mixed source of protein and n-3 polyunsaturated fatty acids from Antarctic krill (Euphausia superba), on hepatic gene expression was analyzed in CBA/J mice. Mice were fed a low-fat control diet or a 3% (w/w) krill powder low-fat diet for 3 months. Gene expression profiling on liver samples revealed that the krill powder supplemented diet modulated a large number of pathways compared to the control diet. Metabolic pathways that were down-regulated included β-oxidation, glucose metabolism, and amino acid catabolism. In contrast, the mitochondrial electron transport chain pathway was upregulated. Krill powder affected more pathways involved in protein metabolism than krill oil. Thus, a krill powder supplemented diet had potent and specific effects on energy metabolism and oxidative phosphorylation at the gene level. This indicates that krill powder supplementation could be an approach to prevent decline in mitochondrial respiratory chain function.http://www.sciencedirect.com/science/article/pii/S1756464613002570Euphausia superbaPolyunsaturated fatty acidsEPADHADietary proteinsEnergy metabolism |
| spellingShingle | Bodil Bjørndal Kjetil Berge Jamie L. Barger Rolf K. Berge Lena Burri A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice Journal of Functional Foods Euphausia superba Polyunsaturated fatty acids EPA DHA Dietary proteins Energy metabolism |
| title | A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
| title_full | A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
| title_fullStr | A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
| title_full_unstemmed | A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
| title_short | A krill powder-diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation, a study of the hepatic transcriptome in mice |
| title_sort | krill powder diet reduces fatty acid and amino acid catabolism while increasing mitochondrial oxidative phosphorylation a study of the hepatic transcriptome in mice |
| topic | Euphausia superba Polyunsaturated fatty acids EPA DHA Dietary proteins Energy metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S1756464613002570 |
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