A2 Adenosine Receptor Subtypes Overproduction in Atria of Perioperative Atrial Fibrillation Patients Undergoing Cardiac Surgery: A Pilot Study
Objective: Although atrial fibrillation is a common cardiac arrhythmia in humans, the mechanism that leads to the onset of this condition is poorly elucidated. Adenosine is suspected to be implicated in the trigger of atrial fibrillation (AF) through the activation of its membrane receptors, mainly...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.761164/full |
| _version_ | 1819044918090268672 |
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| author | Baptiste Maille Baptiste Maille Julien Fromonot Julien Fromonot Claire Guiol Marion Marlinge Marion Marlinge Florian Baptiste Florian Baptiste Florian Baptiste Suzy Lim Charlotte Colombani Marie Charlotte Chaptal Mohamed Chefrour Marguerite Gastaldi Frederic Franceschi Frederic Franceschi Jean-Claude Deharo Jean-Claude Deharo Vlad Gariboldi Vlad Gariboldi Jean Ruf Giovanna Mottola Régis Guieu Régis Guieu |
| author_facet | Baptiste Maille Baptiste Maille Julien Fromonot Julien Fromonot Claire Guiol Marion Marlinge Marion Marlinge Florian Baptiste Florian Baptiste Florian Baptiste Suzy Lim Charlotte Colombani Marie Charlotte Chaptal Mohamed Chefrour Marguerite Gastaldi Frederic Franceschi Frederic Franceschi Jean-Claude Deharo Jean-Claude Deharo Vlad Gariboldi Vlad Gariboldi Jean Ruf Giovanna Mottola Régis Guieu Régis Guieu |
| author_sort | Baptiste Maille |
| collection | DOAJ |
| description | Objective: Although atrial fibrillation is a common cardiac arrhythmia in humans, the mechanism that leads to the onset of this condition is poorly elucidated. Adenosine is suspected to be implicated in the trigger of atrial fibrillation (AF) through the activation of its membrane receptors, mainly adenosine receptor (AR) subtypes A1R and A2R. In this study, we compared blood adenosine concentration (BAC), and A1R, A2AR, and A2BR production in right (RA) and left atrium (LA), and on peripheral blood mononuclear cells (PBMCs) in patients with underlying structural heart disease undergoing cardiac surgery with or without peri-operative AF (PeOpAF).Methods: The study group consisted of 39 patients (30 men and 9 women, mean age, range 65 [40–82] years) undergoing cardiac surgery and 20 healthy patients (8 women and 12 men; mean age, range 60 [39–72] years) as controls were included. Among patients, 15 exhibited PeOpAF.Results: Blood adenosine concentration was higher in patients with PeOpAF than others. A2AR and A2BR production was higher in PBMCs of patients compared with controls and was higher in PeOpAF patients than other patients. In LA and RA, the production of A2AR and A2BR was higher in patients with PeOpAF than in other patients. Both A2AR and A2BR production were higher in LA vs. RA. A1R production was unchanged in all situations. Finally, we observed a correlation between A1R, A2AR, and A2BR production evaluated on PBMCs and those evaluated in LA and RA.Conclusions: Perioperative AF was associated with high BAC and high A2AR and A2BR expression, especially in the LA, after cardiac surgery in patients with underlying structural heart disease. Whether these increases the favor in triggering the AF in this patient population needs further investigation. |
| first_indexed | 2024-12-21T10:20:18Z |
| format | Article |
| id | doaj.art-5cb72c5f6252464fa4b42fbb8a82a33f |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-21T10:20:18Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-5cb72c5f6252464fa4b42fbb8a82a33f2022-12-21T19:07:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-11-01810.3389/fcvm.2021.761164761164A2 Adenosine Receptor Subtypes Overproduction in Atria of Perioperative Atrial Fibrillation Patients Undergoing Cardiac Surgery: A Pilot StudyBaptiste Maille0Baptiste Maille1Julien Fromonot2Julien Fromonot3Claire Guiol4Marion Marlinge5Marion Marlinge6Florian Baptiste7Florian Baptiste8Florian Baptiste9Suzy Lim10Charlotte Colombani11Marie Charlotte Chaptal12Mohamed Chefrour13Marguerite Gastaldi14Frederic Franceschi15Frederic Franceschi16Jean-Claude Deharo17Jean-Claude Deharo18Vlad Gariboldi19Vlad Gariboldi20Jean Ruf21Giovanna Mottola22Régis Guieu23Régis Guieu24Aix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceDepartment of Cardiology, Timone University Hospital, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceLaboratory of Biochemistry, Timone University Hospital, AP-HM, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceLaboratory of Biochemistry, Timone University Hospital, AP-HM, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceDepartment of Cardiology, Timone University Hospital, Marseille, FranceLaboratory of Biochemistry, Timone University Hospital, AP-HM, Marseille, FranceLaboratory of Biochemistry, Timone University Hospital, AP-HM, Marseille, FranceLaboratory of Biochemistry, Timone University Hospital, AP-HM, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceLaboratory of Biochemistry, Timone University Hospital, AP-HM, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceDepartment of Cardiology, Timone University Hospital, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceDepartment of Cardiology, Timone University Hospital, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceDepartment of Cardiac Surgery, Timone University Hospital, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceAix Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceLaboratory of Biochemistry, Timone University Hospital, AP-HM, Marseille, FranceObjective: Although atrial fibrillation is a common cardiac arrhythmia in humans, the mechanism that leads to the onset of this condition is poorly elucidated. Adenosine is suspected to be implicated in the trigger of atrial fibrillation (AF) through the activation of its membrane receptors, mainly adenosine receptor (AR) subtypes A1R and A2R. In this study, we compared blood adenosine concentration (BAC), and A1R, A2AR, and A2BR production in right (RA) and left atrium (LA), and on peripheral blood mononuclear cells (PBMCs) in patients with underlying structural heart disease undergoing cardiac surgery with or without peri-operative AF (PeOpAF).Methods: The study group consisted of 39 patients (30 men and 9 women, mean age, range 65 [40–82] years) undergoing cardiac surgery and 20 healthy patients (8 women and 12 men; mean age, range 60 [39–72] years) as controls were included. Among patients, 15 exhibited PeOpAF.Results: Blood adenosine concentration was higher in patients with PeOpAF than others. A2AR and A2BR production was higher in PBMCs of patients compared with controls and was higher in PeOpAF patients than other patients. In LA and RA, the production of A2AR and A2BR was higher in patients with PeOpAF than in other patients. Both A2AR and A2BR production were higher in LA vs. RA. A1R production was unchanged in all situations. Finally, we observed a correlation between A1R, A2AR, and A2BR production evaluated on PBMCs and those evaluated in LA and RA.Conclusions: Perioperative AF was associated with high BAC and high A2AR and A2BR expression, especially in the LA, after cardiac surgery in patients with underlying structural heart disease. Whether these increases the favor in triggering the AF in this patient population needs further investigation.https://www.frontiersin.org/articles/10.3389/fcvm.2021.761164/fullatrial fibrillationadenosine receptorcardiac surgeryperioperative atrial fibrillationadenosine receptor 2Aadenosine receptor 2B |
| spellingShingle | Baptiste Maille Baptiste Maille Julien Fromonot Julien Fromonot Claire Guiol Marion Marlinge Marion Marlinge Florian Baptiste Florian Baptiste Florian Baptiste Suzy Lim Charlotte Colombani Marie Charlotte Chaptal Mohamed Chefrour Marguerite Gastaldi Frederic Franceschi Frederic Franceschi Jean-Claude Deharo Jean-Claude Deharo Vlad Gariboldi Vlad Gariboldi Jean Ruf Giovanna Mottola Régis Guieu Régis Guieu A2 Adenosine Receptor Subtypes Overproduction in Atria of Perioperative Atrial Fibrillation Patients Undergoing Cardiac Surgery: A Pilot Study Frontiers in Cardiovascular Medicine atrial fibrillation adenosine receptor cardiac surgery perioperative atrial fibrillation adenosine receptor 2A adenosine receptor 2B |
| title | A2 Adenosine Receptor Subtypes Overproduction in Atria of Perioperative Atrial Fibrillation Patients Undergoing Cardiac Surgery: A Pilot Study |
| title_full | A2 Adenosine Receptor Subtypes Overproduction in Atria of Perioperative Atrial Fibrillation Patients Undergoing Cardiac Surgery: A Pilot Study |
| title_fullStr | A2 Adenosine Receptor Subtypes Overproduction in Atria of Perioperative Atrial Fibrillation Patients Undergoing Cardiac Surgery: A Pilot Study |
| title_full_unstemmed | A2 Adenosine Receptor Subtypes Overproduction in Atria of Perioperative Atrial Fibrillation Patients Undergoing Cardiac Surgery: A Pilot Study |
| title_short | A2 Adenosine Receptor Subtypes Overproduction in Atria of Perioperative Atrial Fibrillation Patients Undergoing Cardiac Surgery: A Pilot Study |
| title_sort | a2 adenosine receptor subtypes overproduction in atria of perioperative atrial fibrillation patients undergoing cardiac surgery a pilot study |
| topic | atrial fibrillation adenosine receptor cardiac surgery perioperative atrial fibrillation adenosine receptor 2A adenosine receptor 2B |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.761164/full |
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