ANTIBIOTIC- ASSOCIATED RISK THE REDUCTION OF LACTOBACILLUS SPP. IN THE INTESTINAL MICROBIOTA IN PATIENTS WITH URINARY TRACT INFECTIONS
The aim of our study was to evaluate a risk reduction of indigenous gut microbiota in patients with urinary tract infection (UTI, associated with the intake of antibacterial medicinal products Materials and methods. To this retrospective cohort case-control study were involved 233 women with UTI...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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National Kidney Foundation of Ukraine
2017-06-01
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| Series: | Український Журнал Нефрології та Діалізу |
| Subjects: | |
| Online Access: | https://ukrjnd.com.ua/index.php/journal/article/view/223 |
| _version_ | 1827265300549074944 |
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| author | N. Stepanova N. Stashevska L. Lebid S. Savchenko M. Kolesnyk |
| author_facet | N. Stepanova N. Stashevska L. Lebid S. Savchenko M. Kolesnyk |
| author_sort | N. Stepanova |
| collection | DOAJ |
| description |
The aim of our study was to evaluate a risk reduction of indigenous gut microbiota in patients with urinary tract infection (UTI, associated with the intake of antibacterial medicinal products
Materials and methods. To this retrospective cohort case-control study were involved 233 women with UTI. The mean age in the patient population was 36.7 ± 15.6 years. Cases were defined as reducing the number of Lactobacillus spp. < 10 million colony forming units in 1 g offeces (mln. CFU/g). We evaluated the daily urinary oxalate excretion and bacteriological seeding feces. Investigational antibiotics were medicines which are generally used to treat the outpatient with UTI.
Results. The data analysis demonstrated an extremely high risk the reducing of Lactobacillus spp. colonization in the patient’s intestine. The use of ciprofloxacin was significantly associated with an availability of hyperoxaluria ( = 0.31,
p = 0.008).
Conclusions. Thus, the use of antibacterial medicinal products, even in prophylactic doses, by the patients with UTI leads to the destruction of the normal composition of gut microbiota, and, primarily, due to the fact that the content of Lactobacillus spp. is deceased.
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| first_indexed | 2024-04-24T23:41:13Z |
| format | Article |
| id | doaj.art-5cb7ad51c14f4e66b79a03024eab838a |
| institution | Directory Open Access Journal |
| issn | 2304-0238 2616-7352 |
| language | English |
| last_indexed | 2025-03-22T03:59:46Z |
| publishDate | 2017-06-01 |
| publisher | National Kidney Foundation of Ukraine |
| record_format | Article |
| series | Український Журнал Нефрології та Діалізу |
| spelling | doaj.art-5cb7ad51c14f4e66b79a03024eab838a2024-04-28T10:37:28ZengNational Kidney Foundation of UkraineУкраїнський Журнал Нефрології та Діалізу2304-02382616-73522017-06-012(54)10.31450/ukrjnd.2(54).2017.05223ANTIBIOTIC- ASSOCIATED RISK THE REDUCTION OF LACTOBACILLUS SPP. IN THE INTESTINAL MICROBIOTA IN PATIENTS WITH URINARY TRACT INFECTIONSN. Stepanova0N. Stashevska1L. Lebid2S. Savchenko3M. Kolesnyk4SI «Institute of Nephrology NAMS of Ukraine»SI «Institute of Nephrology NAMS of Ukraine»National Academy of Statistics, Accounting and AuditSI «Institute of Nephrology NAMS of Ukraine»SI «Institute of Nephrology NAMS of Ukraine» The aim of our study was to evaluate a risk reduction of indigenous gut microbiota in patients with urinary tract infection (UTI, associated with the intake of antibacterial medicinal products Materials and methods. To this retrospective cohort case-control study were involved 233 women with UTI. The mean age in the patient population was 36.7 ± 15.6 years. Cases were defined as reducing the number of Lactobacillus spp. < 10 million colony forming units in 1 g offeces (mln. CFU/g). We evaluated the daily urinary oxalate excretion and bacteriological seeding feces. Investigational antibiotics were medicines which are generally used to treat the outpatient with UTI. Results. The data analysis demonstrated an extremely high risk the reducing of Lactobacillus spp. colonization in the patient’s intestine. The use of ciprofloxacin was significantly associated with an availability of hyperoxaluria ( = 0.31, p = 0.008). Conclusions. Thus, the use of antibacterial medicinal products, even in prophylactic doses, by the patients with UTI leads to the destruction of the normal composition of gut microbiota, and, primarily, due to the fact that the content of Lactobacillus spp. is deceased. https://ukrjnd.com.ua/index.php/journal/article/view/223lactobacilli, intestine, antibacterial drugs, hyperoxaluria. |
| spellingShingle | N. Stepanova N. Stashevska L. Lebid S. Savchenko M. Kolesnyk ANTIBIOTIC- ASSOCIATED RISK THE REDUCTION OF LACTOBACILLUS SPP. IN THE INTESTINAL MICROBIOTA IN PATIENTS WITH URINARY TRACT INFECTIONS Український Журнал Нефрології та Діалізу lactobacilli, intestine, antibacterial drugs, hyperoxaluria. |
| title | ANTIBIOTIC- ASSOCIATED RISK THE REDUCTION OF LACTOBACILLUS SPP. IN THE INTESTINAL MICROBIOTA IN PATIENTS WITH URINARY TRACT INFECTIONS |
| title_full | ANTIBIOTIC- ASSOCIATED RISK THE REDUCTION OF LACTOBACILLUS SPP. IN THE INTESTINAL MICROBIOTA IN PATIENTS WITH URINARY TRACT INFECTIONS |
| title_fullStr | ANTIBIOTIC- ASSOCIATED RISK THE REDUCTION OF LACTOBACILLUS SPP. IN THE INTESTINAL MICROBIOTA IN PATIENTS WITH URINARY TRACT INFECTIONS |
| title_full_unstemmed | ANTIBIOTIC- ASSOCIATED RISK THE REDUCTION OF LACTOBACILLUS SPP. IN THE INTESTINAL MICROBIOTA IN PATIENTS WITH URINARY TRACT INFECTIONS |
| title_short | ANTIBIOTIC- ASSOCIATED RISK THE REDUCTION OF LACTOBACILLUS SPP. IN THE INTESTINAL MICROBIOTA IN PATIENTS WITH URINARY TRACT INFECTIONS |
| title_sort | antibiotic associated risk the reduction of lactobacillus spp in the intestinal microbiota in patients with urinary tract infections |
| topic | lactobacilli, intestine, antibacterial drugs, hyperoxaluria. |
| url | https://ukrjnd.com.ua/index.php/journal/article/view/223 |
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