Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis

Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis

Cancer cells are known to undergo metabolic adaptation to cater to their enhanced energy demand. Nicotinamide adenine dinucleotide (NAD) is an essential metabolite regulating many cellular processes within the cell. The enzymes required for NAD synthesis, starting from the base precursor - tryptopha...

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Bibliographic Details
Main Authors: Adithya Chedere, Madhulika Mishra, Omkar Kulkarni, Shrisruti Sriraman, Nagasuma Chandra
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
NAD metabolism
pathway model
NAPRT
NAMPT
liver cancer
precision medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.954512/full

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