Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis
It is well-known that serum and cellular concentrations of zinc are altered in breast cancer patients. Specifically, there are notable zinc hyper-aggregates in breast tumor cells when compared to normal mammary epithelial cells. However, the mechanisms responsible for zinc accumulation and the conse...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/11/1672 |
| _version_ | 1797465840435593216 |
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| author | Mellisa Renteria Ofek Belkin Justin Aickareth David Jang Majd Hawwar Jun Zhang |
| author_facet | Mellisa Renteria Ofek Belkin Justin Aickareth David Jang Majd Hawwar Jun Zhang |
| author_sort | Mellisa Renteria |
| collection | DOAJ |
| description | It is well-known that serum and cellular concentrations of zinc are altered in breast cancer patients. Specifically, there are notable zinc hyper-aggregates in breast tumor cells when compared to normal mammary epithelial cells. However, the mechanisms responsible for zinc accumulation and the consequences of zinc dysregulation are poorly understood. In this review, we detailed cellular zinc regulation/dysregulation under the influence of varying levels of sex steroids and breast cancer tumorigenesis to try to better understand the intricate relationship between these factors based on our current understanding of the CmPn/CmP signaling network. We also made some efforts to propose a relationship between zinc signaling and the CmPn/CmP signaling network. |
| first_indexed | 2024-03-09T18:27:18Z |
| format | Article |
| id | doaj.art-5cba6b6b4500441aa4e6eebd6bfa7c39 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T18:27:18Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-5cba6b6b4500441aa4e6eebd6bfa7c392023-11-24T07:47:33ZengMDPI AGBiomolecules2218-273X2022-11-011211167210.3390/biom12111672Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer TumorigenesisMellisa Renteria0Ofek Belkin1Justin Aickareth2David Jang3Majd Hawwar4Jun Zhang5Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USADepartment of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USADepartment of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USADepartment of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USADepartment of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USADepartment of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USAIt is well-known that serum and cellular concentrations of zinc are altered in breast cancer patients. Specifically, there are notable zinc hyper-aggregates in breast tumor cells when compared to normal mammary epithelial cells. However, the mechanisms responsible for zinc accumulation and the consequences of zinc dysregulation are poorly understood. In this review, we detailed cellular zinc regulation/dysregulation under the influence of varying levels of sex steroids and breast cancer tumorigenesis to try to better understand the intricate relationship between these factors based on our current understanding of the CmPn/CmP signaling network. We also made some efforts to propose a relationship between zinc signaling and the CmPn/CmP signaling network.https://www.mdpi.com/2218-273X/12/11/1672ZincCmPn signaling networkCmP signaling networkCCM signaling complex (CSC)progesterone (PRG)classic nuclear progesterone receptors (nPRs) |
| spellingShingle | Mellisa Renteria Ofek Belkin Justin Aickareth David Jang Majd Hawwar Jun Zhang Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis Biomolecules Zinc CmPn signaling network CmP signaling network CCM signaling complex (CSC) progesterone (PRG) classic nuclear progesterone receptors (nPRs) |
| title | Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis |
| title_full | Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis |
| title_fullStr | Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis |
| title_full_unstemmed | Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis |
| title_short | Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis |
| title_sort | zinc s association with the cmpn cmp signaling network in breast cancer tumorigenesis |
| topic | Zinc CmPn signaling network CmP signaling network CCM signaling complex (CSC) progesterone (PRG) classic nuclear progesterone receptors (nPRs) |
| url | https://www.mdpi.com/2218-273X/12/11/1672 |
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