Mitochondrial depolarization promotes calcium alternans: Mechanistic insights from a ventricular myocyte model.
Mitochondria are vital organelles inside the cell and contribute to intracellular calcium (Ca2+) dynamics directly and indirectly via calcium exchange, ATP generation, and production of reactive oxygen species (ROS). Arrhythmogenic Ca2+ alternans in cardiac myocytes has been observed in experiments...
Main Authors: | Vikas Pandey, Lai-Hua Xie, Zhilin Qu, Zhen Song |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-01-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1008624 |
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