| Summary: | Ayoob Lone,1 Azzam Othman Albotuaiba2 1Department of Clinical Neurosciences, College of Medicine, King Faisal University, AlHasa, 31982, Saudi Arabia; 2College of Medicine, King Faisal University, AlHasa, 31982, Saudi ArabiaCorrespondence: Ayoob Lone, Tel +966553039056, Email mlone@kfu.edu.saBackground: The association between personality traits and hypertension is complex and has so far not been studied in depth.Objective: The present study aims to explore the connection between the Big Five personality traits and hypertension.Methods: This case control study includes 310 participants, and the relationship between personality traits and hypertension was investigated in normotensive and hypertensive patients by the Big Five Inventory-10. We examined the association of each of the Big Five personality traits in hypertensive patients and a control group using binary logistic regression analysis.Results: The findings of the study revealed that amongst the Big Five personality factors, low conscientiousness (OR: 1.09, 95% CI: 0.92– 1.29, P< 0.005) and high neuroticism (OR: 0.54, 95% CI: 0.45– 0.66, P< 0.001) were related with high risk of hypertension. Male, older people, and physically inactive individuals have been found to be at a higher risk of hypertension. No significant relationship was found between hypertension and marital status, education, or smoking habits.Conclusion: These results suggested that a low score in conscientiousness trait and a high neuroticism score may be an additional risk factor of hypertension. Thus, it may be worthy to investigate further in order to identify patients at risk and develop a more individual treatment strategy. Cognitive behavioral therapy and pharmacological options can be used preemptively in high-risk patients.Keywords: Big Five personality, hypertension, conscientiousness, neuroticism
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