<i>Bauhinia forficata</i> Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine Model
<i>Bauhinia forficata</i> L. is a tree used in alternative medicine as an anti-diabetic agent, with little scientific information about its pharmacological properties. The hypoglycemic, antioxidant, and genoprotective activities of a methanolic extract of <i>B</i>. <i>f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/11/22/3052 |
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| author | Erika Anayetzi Chávez-Bustos Angel Morales-González Liliana Anguiano-Robledo Eduardo Osiris Madrigal-Santillán Cármen Valadez-Vega Olivia Lugo-Magaña Jorge Alberto Mendoza-Pérez Tomás Alejandro Fregoso-Aguilar |
| author_facet | Erika Anayetzi Chávez-Bustos Angel Morales-González Liliana Anguiano-Robledo Eduardo Osiris Madrigal-Santillán Cármen Valadez-Vega Olivia Lugo-Magaña Jorge Alberto Mendoza-Pérez Tomás Alejandro Fregoso-Aguilar |
| author_sort | Erika Anayetzi Chávez-Bustos |
| collection | DOAJ |
| description | <i>Bauhinia forficata</i> L. is a tree used in alternative medicine as an anti-diabetic agent, with little scientific information about its pharmacological properties. The hypoglycemic, antioxidant, and genoprotective activities of a methanolic extract of <i>B</i>. <i>forficata</i> leaves and stems combined were investigated in mice treated with streptozotocin (STZ). Secondary metabolites were determined by qualitative phytochemistry. In vitro antioxidant activity was determined by the DPPH method at four concentrations of the extract. The genoprotective activity was evaluated in 3 groups of mice: control, anthracene (10 mg/kg), and anthracene + <i>B. forficata</i> (500 mg/kg) and the presence of micronuclei in peripheral blood was measured for 2 weeks. To determine the hypoglycemic activity, the crude extract was prepared in a suspension and administered (500 mg/kg, i.g.) in previously diabetic mice with STZ (120 mg/kg, i.p.), measuring blood glucose levels every week as well as the animals’ body weight for six weeks. The extract showed good antioxidant activity and caused a decrease in the number of micronuclei. The diabetic mice + <i>B</i>. <i>forficata</i> presented hypoglycemic effects in the third week of treatment, perhaps due to its secondary metabolites. Therefore, <i>B. forficata</i> is a candidate for continued use at the ethnomedical level as an adjuvant to allopathic therapy. |
| first_indexed | 2024-03-09T18:03:56Z |
| format | Article |
| id | doaj.art-5cc0ef43d2e049aa9c79578afff6d81f |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-09T18:03:56Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-5cc0ef43d2e049aa9c79578afff6d81f2023-11-24T09:38:51ZengMDPI AGPlants2223-77472022-11-011122305210.3390/plants11223052<i>Bauhinia forficata</i> Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine ModelErika Anayetzi Chávez-Bustos0Angel Morales-González1Liliana Anguiano-Robledo2Eduardo Osiris Madrigal-Santillán3Cármen Valadez-Vega4Olivia Lugo-Magaña5Jorge Alberto Mendoza-Pérez6Tomás Alejandro Fregoso-Aguilar7Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Department de Fisiología. Av., Wilfrido Massieu S/N, Col. Nueva Industrial Vallejo, Alcaldía Gustavo A. Madero, Ciudad de México C.P. 07700, MexicoEscuela Superior de Cómputo, Instituto Politécnico Nacional, Av. Juan de Dios Bátiz S/N Esquina Miguel Othón de Mendizabal, Unidad Profesional Adolfo López Mateos, Ciudad de México C.P. 07738, MexicoEscuela Superior de Medicina, Laboratorio de Farmacología Molecular, Instituto Politécnico Nacional, Alcaldía Miguel Hidalgo, Ciudad de México C.P. 11340, MexicoLaboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Alcaldía. Miguel Hidalgo, Ciudad de México C.P. 11340, MexicoÁrea Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, San Agustín Tlaxiaca C.P. 42080, MexicoPreparatoria Número 1, Universidad Autónoma del Estado de Hidalgo, Av. Benito Juárez S/N, Constitución, Pachuca de Soto C.P. 42060, MexicoEscuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Department de Ingeniería en Sistemas Ambientales. Av., Wilfrido Massieu S/N, Col. Nueva Industrial Vallejo, Alcaldía Gustavo A. Madero, Ciudad de México C.P. 07700, MexicoEscuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Department de Fisiología. Av., Wilfrido Massieu S/N, Col. Nueva Industrial Vallejo, Alcaldía Gustavo A. Madero, Ciudad de México C.P. 07700, Mexico<i>Bauhinia forficata</i> L. is a tree used in alternative medicine as an anti-diabetic agent, with little scientific information about its pharmacological properties. The hypoglycemic, antioxidant, and genoprotective activities of a methanolic extract of <i>B</i>. <i>forficata</i> leaves and stems combined were investigated in mice treated with streptozotocin (STZ). Secondary metabolites were determined by qualitative phytochemistry. In vitro antioxidant activity was determined by the DPPH method at four concentrations of the extract. The genoprotective activity was evaluated in 3 groups of mice: control, anthracene (10 mg/kg), and anthracene + <i>B. forficata</i> (500 mg/kg) and the presence of micronuclei in peripheral blood was measured for 2 weeks. To determine the hypoglycemic activity, the crude extract was prepared in a suspension and administered (500 mg/kg, i.g.) in previously diabetic mice with STZ (120 mg/kg, i.p.), measuring blood glucose levels every week as well as the animals’ body weight for six weeks. The extract showed good antioxidant activity and caused a decrease in the number of micronuclei. The diabetic mice + <i>B</i>. <i>forficata</i> presented hypoglycemic effects in the third week of treatment, perhaps due to its secondary metabolites. Therefore, <i>B. forficata</i> is a candidate for continued use at the ethnomedical level as an adjuvant to allopathic therapy.https://www.mdpi.com/2223-7747/11/22/3052<i>Bahuinia forficata</i>diabetesantioxidanthypoglycemic activitymice |
| spellingShingle | Erika Anayetzi Chávez-Bustos Angel Morales-González Liliana Anguiano-Robledo Eduardo Osiris Madrigal-Santillán Cármen Valadez-Vega Olivia Lugo-Magaña Jorge Alberto Mendoza-Pérez Tomás Alejandro Fregoso-Aguilar <i>Bauhinia forficata</i> Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine Model Plants <i>Bahuinia forficata</i> diabetes antioxidant hypoglycemic activity mice |
| title | <i>Bauhinia forficata</i> Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine Model |
| title_full | <i>Bauhinia forficata</i> Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine Model |
| title_fullStr | <i>Bauhinia forficata</i> Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine Model |
| title_full_unstemmed | <i>Bauhinia forficata</i> Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine Model |
| title_short | <i>Bauhinia forficata</i> Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine Model |
| title_sort | i bauhinia forficata i link antioxidant genoprotective and hypoglycemic activity in a murine model |
| topic | <i>Bahuinia forficata</i> diabetes antioxidant hypoglycemic activity mice |
| url | https://www.mdpi.com/2223-7747/11/22/3052 |
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