Stable contacts of naïve CD4 T cells with migratory dendritic cells are ICAM-1-dependent but dispensable for proliferation in vivo

Stable contacts of naïve CD4 T cells with migratory dendritic cells are ICAM-1-dependent but dispensable for proliferation in vivo

It is unclear if naïve T cells require dendritic cell ICAMs to proliferate inside lymph nodes. To check if and when CD4 lymphocytes use ICAMs on migratory DCs, wild-type and ICAM-1 and 2 double knock out bone marrow-derived DCs pulsed with saturating levels of an OT-II transgene-specific ovalbumin-d...

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Bibliographic Details
Main Authors: Stav Kozlovski, Ofir Atrakchi, Sara W Feigelson, Ziv Shulman, Ronen Alon
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Cell Adhesion & Migration
Subjects:
lymph nodes
dendritic cells
integrins
t cell activation
vaccination
Online Access:http://dx.doi.org/10.1080/19336918.2019.1644857

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