TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2

TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2

Summary: The spindle assembly checkpoint (SAC) prevents premature segregation of chromosomes during mitosis. This process requires structural remodeling of MAD2 from O-MAD2 to C-MAD2 conformation. After the checkpoint is satisfied, C-MAD2 is reverted to O-MAD2 to allow anaphase-promoting complex/cyc...

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Bibliographic Details
Main Authors: Hoi Tang Ma, Randy Y.C. Poon
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
MAD2
mitosis
spindle assembly checkpoint
TRIP13
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718300597

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