Vitamin D plasma concentrations in pregnant women and their preterm newborns
Abstract Background Vitamin D deficiency is a global public health issue. More than half of pregnant women are affected by vitamin D insufficiency/deficiency. Studies suggest an association between low vitamin D concentrations during pregnancy with intrauterine growth restriction and prematurity. Th...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | http://link.springer.com/article/10.1186/s12884-018-2045-1 |
| _version_ | 1828768158794645504 |
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| author | Milene Saori Kassai Fernanda Ramirez Cafeo Fernando Alves Affonso-Kaufman Fabíola Isabel Suano-Souza Roseli Oselka Saccardo Sarni |
| author_facet | Milene Saori Kassai Fernanda Ramirez Cafeo Fernando Alves Affonso-Kaufman Fabíola Isabel Suano-Souza Roseli Oselka Saccardo Sarni |
| author_sort | Milene Saori Kassai |
| collection | DOAJ |
| description | Abstract Background Vitamin D deficiency is a global public health issue. More than half of pregnant women are affected by vitamin D insufficiency/deficiency. Studies suggest an association between low vitamin D concentrations during pregnancy with intrauterine growth restriction and prematurity. This study aimed to describe the concentrations of 25(OH)D (25-hydroxyvitamin D) of mothers who delivered preterm newborns compared to women with full-term pregnancy deliveries, as well as to relate 25(OH)D blood concentrations of mothers with those of their newborns. Method This cross-sectional study was conducted with 66 mothers who had given birth to preterm babies and their preterm newborns (PTNB, < 32 weeks), and 92 women who had given birth at the full-term of their pregnancy and their newborns (FTNB). Data were collected on the characteristics of mothers (gestational age, diseases, and habits) and newborns (anthropometry and adequacy for gestational age). Ten milliliters of blood were drawn from the mothers and the umbilical cord of newborns at birth to identify the 25(OH)D, parathyroid hormone, calcium, phosphorus, and alkaline phosphatase concentrations. Results Mothers in the PTNB group had significantly lower mean 25(OH)D blood levels (21.7 ± 10.8 ng/mL vs. 26.2 ± 9.8 ng/mL; p = 0.011) and were three times more likely to have insufficiency when compared to mothers in the FTNB group (OR = 2.993; 95%CI 1.02–8.74). Newborns in the PTNB group also had lower 25(OH)D concentrations compared to FTNB group (25.9 ± 13.9 ng/dL vs. 31.9 ± 12.3 ng/dL; p = 0.009). There was a directly proportional correlation between mother and newborn umbilical cord 25(OH)D concentrations in PTNB (r = 0.596; p < 0.001) and FTNB (r = 0.765; p < 0.001). Conclusion Mothers who delivered preterm babies and their preterm newborns had lower 25(OH)D concentrations compared to women who had given birth at the full-term of their pregnancy. In both groups, 25(OH)D concentrations of the mothers correlated directly with those of the newborns, and this correlation was higher in the full-term birth group. Nevertheless, the recommended universal vitamin D supplementation in pregnant women to curb the risk of preterm birth is still incipient. More studies are required to clarify the particularities of vitamin D metabolism further and define the adequate 25(OH)D concentrations throughout pregnancy. |
| first_indexed | 2024-12-11T07:41:51Z |
| format | Article |
| id | doaj.art-5cc512dcc43f40b8b5ba3da11ca604f6 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-11T07:41:51Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-5cc512dcc43f40b8b5ba3da11ca604f62022-12-22T01:15:33ZengBMCBMC Pregnancy and Childbirth1471-23932018-10-011811810.1186/s12884-018-2045-1Vitamin D plasma concentrations in pregnant women and their preterm newbornsMilene Saori Kassai0Fernanda Ramirez Cafeo1Fernando Alves Affonso-Kaufman2Fabíola Isabel Suano-Souza3Roseli Oselka Saccardo Sarni4Department of Pediatrics, Faculdade de Medicina do ABCDepartment of Pediatrics, Universidade Federal de São Paulo - Escola Paulista de MedicinaDepartment of Pediatrics, Universidade Federal de São Paulo - Escola Paulista de MedicinaDepartment of Pediatrics, Faculdade de Medicina do ABCDepartment of Pediatrics, Faculdade de Medicina do ABCAbstract Background Vitamin D deficiency is a global public health issue. More than half of pregnant women are affected by vitamin D insufficiency/deficiency. Studies suggest an association between low vitamin D concentrations during pregnancy with intrauterine growth restriction and prematurity. This study aimed to describe the concentrations of 25(OH)D (25-hydroxyvitamin D) of mothers who delivered preterm newborns compared to women with full-term pregnancy deliveries, as well as to relate 25(OH)D blood concentrations of mothers with those of their newborns. Method This cross-sectional study was conducted with 66 mothers who had given birth to preterm babies and their preterm newborns (PTNB, < 32 weeks), and 92 women who had given birth at the full-term of their pregnancy and their newborns (FTNB). Data were collected on the characteristics of mothers (gestational age, diseases, and habits) and newborns (anthropometry and adequacy for gestational age). Ten milliliters of blood were drawn from the mothers and the umbilical cord of newborns at birth to identify the 25(OH)D, parathyroid hormone, calcium, phosphorus, and alkaline phosphatase concentrations. Results Mothers in the PTNB group had significantly lower mean 25(OH)D blood levels (21.7 ± 10.8 ng/mL vs. 26.2 ± 9.8 ng/mL; p = 0.011) and were three times more likely to have insufficiency when compared to mothers in the FTNB group (OR = 2.993; 95%CI 1.02–8.74). Newborns in the PTNB group also had lower 25(OH)D concentrations compared to FTNB group (25.9 ± 13.9 ng/dL vs. 31.9 ± 12.3 ng/dL; p = 0.009). There was a directly proportional correlation between mother and newborn umbilical cord 25(OH)D concentrations in PTNB (r = 0.596; p < 0.001) and FTNB (r = 0.765; p < 0.001). Conclusion Mothers who delivered preterm babies and their preterm newborns had lower 25(OH)D concentrations compared to women who had given birth at the full-term of their pregnancy. In both groups, 25(OH)D concentrations of the mothers correlated directly with those of the newborns, and this correlation was higher in the full-term birth group. Nevertheless, the recommended universal vitamin D supplementation in pregnant women to curb the risk of preterm birth is still incipient. More studies are required to clarify the particularities of vitamin D metabolism further and define the adequate 25(OH)D concentrations throughout pregnancy.http://link.springer.com/article/10.1186/s12884-018-2045-1Vitamin DNewbornsPregnancyUmbilical cord |
| spellingShingle | Milene Saori Kassai Fernanda Ramirez Cafeo Fernando Alves Affonso-Kaufman Fabíola Isabel Suano-Souza Roseli Oselka Saccardo Sarni Vitamin D plasma concentrations in pregnant women and their preterm newborns BMC Pregnancy and Childbirth Vitamin D Newborns Pregnancy Umbilical cord |
| title | Vitamin D plasma concentrations in pregnant women and their preterm newborns |
| title_full | Vitamin D plasma concentrations in pregnant women and their preterm newborns |
| title_fullStr | Vitamin D plasma concentrations in pregnant women and their preterm newborns |
| title_full_unstemmed | Vitamin D plasma concentrations in pregnant women and their preterm newborns |
| title_short | Vitamin D plasma concentrations in pregnant women and their preterm newborns |
| title_sort | vitamin d plasma concentrations in pregnant women and their preterm newborns |
| topic | Vitamin D Newborns Pregnancy Umbilical cord |
| url | http://link.springer.com/article/10.1186/s12884-018-2045-1 |
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