ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY
Abstract. The role of hepatitis C virus (HCV) co-infection in violation of restoring CD4+T cells in HIVinfected patients receiving antiretroviral therapy (ART) was investigated. Seventy eight patients with effective virological response to ART (viral load < 50 copies/ml) who either had or had...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/673 |
| _version_ | 1797198013845733376 |
|---|---|
| author | E. V. Saidakova L. B. Korolevskaya N. G. Shmagel K. V. Shmagel V. A. Chereshnev |
| author_facet | E. V. Saidakova L. B. Korolevskaya N. G. Shmagel K. V. Shmagel V. A. Chereshnev |
| author_sort | E. V. Saidakova |
| collection | DOAJ |
| description | Abstract. The role of hepatitis C virus (HCV) co-infection in violation of restoring CD4+T cells in HIVinfected patients receiving antiretroviral therapy (ART) was investigated. Seventy eight patients with effective virological response to ART (viral load < 50 copies/ml) who either had or had no good immunological CD4+Tcell response after two years of treatment were recruited. Twenty one relatively healthy volunteers served as controls. The numbers of main T-lymphocyte populations and their apoptosis rates were determined. Thymus productive function was assessed by the number of αTREC-positive CD4+ and CD8+T cells. It is shown that HIV/HCV co-infection is characterized by lower numbers of CD4+T-lymphocytes in patients’ blood compared with HIV-monoinfection. This is not associated with the cells’ increased death rates. We also demonstrate that HCV coinfection reduces the production of CD4+, but not CD8+T-lymphocytes, by the thymus. |
| first_indexed | 2024-03-08T05:49:38Z |
| format | Article |
| id | doaj.art-5cc9bee1c44047c78726ba830fdb44f9 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:07Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-5cc9bee1c44047c78726ba830fdb44f92024-04-22T13:07:39ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0115654355210.15789/1563-0625-2013-6-543-552670ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPYE. V. Saidakova0L. B. Korolevskaya1N. G. Shmagel2K. V. Shmagel3V. A. Chereshnev4Institute of Ecology and Genetics of Microorganisms, Russian Academy of Sciences, Ural branch, PermInstitute of Ecology and Genetics of Microorganisms, Russian Academy of Sciences, Ural branch, PermPerm Regional Center for Protection against AIDS and Infectious Diseases, PermInstitute of Ecology and Genetics of Microorganisms, Russian Academy of Sciences, Ural branch, PermInstitute of Immunology and Physiology, Russian Academy of Sciences, Ural branch, EkaterinburgAbstract. The role of hepatitis C virus (HCV) co-infection in violation of restoring CD4+T cells in HIVinfected patients receiving antiretroviral therapy (ART) was investigated. Seventy eight patients with effective virological response to ART (viral load < 50 copies/ml) who either had or had no good immunological CD4+Tcell response after two years of treatment were recruited. Twenty one relatively healthy volunteers served as controls. The numbers of main T-lymphocyte populations and their apoptosis rates were determined. Thymus productive function was assessed by the number of αTREC-positive CD4+ and CD8+T cells. It is shown that HIV/HCV co-infection is characterized by lower numbers of CD4+T-lymphocytes in patients’ blood compared with HIV-monoinfection. This is not associated with the cells’ increased death rates. We also demonstrate that HCV coinfection reduces the production of CD4+, but not CD8+T-lymphocytes, by the thymus.https://www.mimmun.ru/mimmun/article/view/673hiv/hcv-coinfectionantiretroviral therapyimmunological areactivityapoptosisthymic productive function |
| spellingShingle | E. V. Saidakova L. B. Korolevskaya N. G. Shmagel K. V. Shmagel V. A. Chereshnev ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY Медицинская иммунология hiv/hcv-coinfection antiretroviral therapy immunological areactivity apoptosis thymic productive function |
| title | ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY |
| title_full | ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY |
| title_fullStr | ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY |
| title_full_unstemmed | ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY |
| title_short | ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY |
| title_sort | role of hepatitis c virus coinfection in violation of productive thymic function in hiv infected patients under immunologically inefficient antiretroviral therapy |
| topic | hiv/hcv-coinfection antiretroviral therapy immunological areactivity apoptosis thymic productive function |
| url | https://www.mimmun.ru/mimmun/article/view/673 |
| work_keys_str_mv | AT evsaidakova roleofhepatitiscviruscoinfectioninviolationofproductivethymicfunctioninhivinfectedpatientsunderimmunologicallyinefficientantiretroviraltherapy AT lbkorolevskaya roleofhepatitiscviruscoinfectioninviolationofproductivethymicfunctioninhivinfectedpatientsunderimmunologicallyinefficientantiretroviraltherapy AT ngshmagel roleofhepatitiscviruscoinfectioninviolationofproductivethymicfunctioninhivinfectedpatientsunderimmunologicallyinefficientantiretroviraltherapy AT kvshmagel roleofhepatitiscviruscoinfectioninviolationofproductivethymicfunctioninhivinfectedpatientsunderimmunologicallyinefficientantiretroviraltherapy AT vachereshnev roleofhepatitiscviruscoinfectioninviolationofproductivethymicfunctioninhivinfectedpatientsunderimmunologicallyinefficientantiretroviraltherapy |