Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo
Action Potential (APs) patterns of sensory cortex neurons encode a variety of stimulus features, but how can a neuron change the feature to which it responds? Here, we show that in vivo a spike-timing-dependent plasticity (STDP) protocol—consisting of pairing a postsynaptic AP with visually driven p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2013-01-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/00012 |
| _version_ | 1811236877656653824 |
|---|---|
| author | Verena Pawlak David S Greenberg Henning Sprekeler Wulfram Gerstner Jason ND Kerr |
| author_facet | Verena Pawlak David S Greenberg Henning Sprekeler Wulfram Gerstner Jason ND Kerr |
| author_sort | Verena Pawlak |
| collection | DOAJ |
| description | Action Potential (APs) patterns of sensory cortex neurons encode a variety of stimulus features, but how can a neuron change the feature to which it responds? Here, we show that in vivo a spike-timing-dependent plasticity (STDP) protocol—consisting of pairing a postsynaptic AP with visually driven presynaptic inputs—modifies a neurons' AP-response in a bidirectional way that depends on the relative AP-timing during pairing. Whereas postsynaptic APs repeatedly following presynaptic activation can convert subthreshold into suprathreshold responses, APs repeatedly preceding presynaptic activation reduce AP responses to visual stimulation. These changes were paralleled by restructuring of the neurons response to surround stimulus locations and membrane-potential time-course. Computational simulations could reproduce the observed subthreshold voltage changes only when presynaptic temporal jitter was included. Together this shows that STDP rules can modify output patterns of sensory neurons and the timing of single-APs plays a crucial role in sensory coding and plasticity. |
| first_indexed | 2024-04-12T12:15:42Z |
| format | Article |
| id | doaj.art-5ccc12d6b5f24e93893c4bfd2fa34f2c |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:15:42Z |
| publishDate | 2013-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-5ccc12d6b5f24e93893c4bfd2fa34f2c2022-12-22T03:33:26ZengeLife Sciences Publications LtdeLife2050-084X2013-01-01210.7554/eLife.00012Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivoVerena Pawlak0David S Greenberg1Henning Sprekeler2Wulfram Gerstner3Jason ND Kerr4Network Imaging Group, Max Planck Institute for Biological Cybernetics, Tübingen, GermanyNetwork Imaging Group, Max Planck Institute for Biological Cybernetics, Tübingen, GermanySchool of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, SwitzerlandSchool of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; Bernstein Center for Computational Neuroscience, Tübingen, GermanyNetwork Imaging Group, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; Bernstein Center for Computational Neuroscience, Tübingen, GermanyAction Potential (APs) patterns of sensory cortex neurons encode a variety of stimulus features, but how can a neuron change the feature to which it responds? Here, we show that in vivo a spike-timing-dependent plasticity (STDP) protocol—consisting of pairing a postsynaptic AP with visually driven presynaptic inputs—modifies a neurons' AP-response in a bidirectional way that depends on the relative AP-timing during pairing. Whereas postsynaptic APs repeatedly following presynaptic activation can convert subthreshold into suprathreshold responses, APs repeatedly preceding presynaptic activation reduce AP responses to visual stimulation. These changes were paralleled by restructuring of the neurons response to surround stimulus locations and membrane-potential time-course. Computational simulations could reproduce the observed subthreshold voltage changes only when presynaptic temporal jitter was included. Together this shows that STDP rules can modify output patterns of sensory neurons and the timing of single-APs plays a crucial role in sensory coding and plasticity.https://elifesciences.org/articles/00012synaptic plasticitySTDPvisual cortexcircuitin vivospiking pattern |
| spellingShingle | Verena Pawlak David S Greenberg Henning Sprekeler Wulfram Gerstner Jason ND Kerr Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo eLife synaptic plasticity STDP visual cortex circuit in vivo spiking pattern |
| title | Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo |
| title_full | Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo |
| title_fullStr | Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo |
| title_full_unstemmed | Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo |
| title_short | Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo |
| title_sort | changing the responses of cortical neurons from sub to suprathreshold using single spikes in vivo |
| topic | synaptic plasticity STDP visual cortex circuit in vivo spiking pattern |
| url | https://elifesciences.org/articles/00012 |
| work_keys_str_mv | AT verenapawlak changingtheresponsesofcorticalneuronsfromsubtosuprathresholdusingsinglespikesinvivo AT davidsgreenberg changingtheresponsesofcorticalneuronsfromsubtosuprathresholdusingsinglespikesinvivo AT henningsprekeler changingtheresponsesofcorticalneuronsfromsubtosuprathresholdusingsinglespikesinvivo AT wulframgerstner changingtheresponsesofcorticalneuronsfromsubtosuprathresholdusingsinglespikesinvivo AT jasonndkerr changingtheresponsesofcorticalneuronsfromsubtosuprathresholdusingsinglespikesinvivo |