Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention. The activity of these co...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/23/12/3361 |
| _version_ | 1811271960021172224 |
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| author | Teresa Glomb Karolina Szymankiewicz Piotr Świątek |
| author_facet | Teresa Glomb Karolina Szymankiewicz Piotr Świątek |
| author_sort | Teresa Glomb |
| collection | DOAJ |
| description | Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention. The activity of these compounds was tested on cell lines of various cancers. In most publications, the most active derivatives of 1,3,4-oxadiazole exceeded the effect of reference drugs, so they may become the main new anti-cancer drugs in the future. |
| first_indexed | 2024-04-12T22:31:36Z |
| format | Article |
| id | doaj.art-5ccc4a1727984e818ecdeea098c5de6c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T22:31:36Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5ccc4a1727984e818ecdeea098c5de6c2022-12-22T03:13:58ZengMDPI AGMolecules1420-30492018-12-012312336110.3390/molecules23123361molecules23123361Anti-Cancer Activity of Derivatives of 1,3,4-OxadiazoleTeresa Glomb0Karolina Szymankiewicz1Piotr Świątek2Department of Chemistry of Drugs, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, PolandDepartment of Chemistry of Drugs, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, PolandDepartment of Chemistry of Drugs, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, PolandCompounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention. The activity of these compounds was tested on cell lines of various cancers. In most publications, the most active derivatives of 1,3,4-oxadiazole exceeded the effect of reference drugs, so they may become the main new anti-cancer drugs in the future.https://www.mdpi.com/1420-3049/23/12/33611,3,4-oxadiazoleanti-proliferative activityanti-cancer drugs |
| spellingShingle | Teresa Glomb Karolina Szymankiewicz Piotr Świątek Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole Molecules 1,3,4-oxadiazole anti-proliferative activity anti-cancer drugs |
| title | Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole |
| title_full | Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole |
| title_fullStr | Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole |
| title_full_unstemmed | Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole |
| title_short | Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole |
| title_sort | anti cancer activity of derivatives of 1 3 4 oxadiazole |
| topic | 1,3,4-oxadiazole anti-proliferative activity anti-cancer drugs |
| url | https://www.mdpi.com/1420-3049/23/12/3361 |
| work_keys_str_mv | AT teresaglomb anticanceractivityofderivativesof134oxadiazole AT karolinaszymankiewicz anticanceractivityofderivativesof134oxadiazole AT piotrswiatek anticanceractivityofderivativesof134oxadiazole |