Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective
Bronchiolitis obliterans syndrome (BOS) is the most common form of CLAD and is characterized by airflow limitation and an obstructive spirometric pattern without high-resolution computed tomography (HRCT) evidence of parenchymal opacities. Computed tomography and microCT analysis show abundant small...
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MDPI AG
2022-12-01
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| Schriftenreihe: | Biomedicines |
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| Online Zugang: | https://www.mdpi.com/2227-9059/10/12/3277 |
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| author | Dalila Cavallaro Marco Guerrieri Stefano Cattelan Gaia Fabbri Sara Croce Martina Armati David Bennett Antonella Fossi Luca Voltolini Luca Luzzi Alberto Salvicchi Piero Paladini Adriano Peris Miriana d’Alessandro Paolo Cameli Elena Bargagli Tuscany Transplant Group Laura Bergantini |
| author_facet | Dalila Cavallaro Marco Guerrieri Stefano Cattelan Gaia Fabbri Sara Croce Martina Armati David Bennett Antonella Fossi Luca Voltolini Luca Luzzi Alberto Salvicchi Piero Paladini Adriano Peris Miriana d’Alessandro Paolo Cameli Elena Bargagli Tuscany Transplant Group Laura Bergantini |
| author_sort | Dalila Cavallaro |
| collection | DOAJ |
| description | Bronchiolitis obliterans syndrome (BOS) is the most common form of CLAD and is characterized by airflow limitation and an obstructive spirometric pattern without high-resolution computed tomography (HRCT) evidence of parenchymal opacities. Computed tomography and microCT analysis show abundant small airway obstruction, starting from the fifth generation of airway branching and affecting up to 40–70% of airways. The pathogenesis of BOS remains unclear. It is a multifactorial syndrome that leads to pathological tissue changes and clinical manifestations. Because BOS is associated with the worst long-term survival in LTx patients, many studies are focused on the early identification of BOS. Markers may be useful for diagnosis and for understanding the molecular and immunological mechanisms involved in the onset of BOS. Diagnostic and predictive markers of BOS have also been investigated in various biological materials, such as blood, BAL, lung tissue and extracellular vesicles. The aim of this review was to evaluate the scientific literature on markers of BOS after lung transplant. We performed a systematic review to find all available data on potential prognostic and diagnostic markers of BOS. |
| first_indexed | 2024-03-09T17:17:11Z |
| format | Article |
| id | doaj.art-5ccf859e1eee4c4aa2d775443c2ca634 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:17:11Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5ccf859e1eee4c4aa2d775443c2ca6342023-11-24T13:29:56ZengMDPI AGBiomedicines2227-90592022-12-011012327710.3390/biomedicines10123277Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future PerspectiveDalila Cavallaro0Marco Guerrieri1Stefano Cattelan2Gaia Fabbri3Sara Croce4Martina Armati5David Bennett6Antonella Fossi7Luca Voltolini8Luca Luzzi9Alberto Salvicchi10Piero Paladini11Adriano Peris12Miriana d’Alessandro13Paolo Cameli14Elena Bargagli15Tuscany Transplant Group16Laura Bergantini17Respiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyThoracic Surgery Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliero-Universitaria Careggi, 50134 Firenze, ItalyLung Transplant Unit, Department of Medical, Surgical and Neuro Sciences, Azienda Ospedaliero-Universitaria Senese, University of Siena, 53100 Siena, ItalyThoracic Surgery Unit, Department of Experimental and Clinical Medicine, Azienda Ospedaliero-Universitaria Careggi, 50134 Firenze, ItalyLung Transplant Unit, Department of Medical, Surgical and Neuro Sciences, Azienda Ospedaliero-Universitaria Senese, University of Siena, 53100 Siena, ItalyOrganizzazione Toscana Trapianti, Regione Toscana, 50134 Firenze, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyRespiratory Disease and Lung Transplant Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 53100 Siena, ItalyBronchiolitis obliterans syndrome (BOS) is the most common form of CLAD and is characterized by airflow limitation and an obstructive spirometric pattern without high-resolution computed tomography (HRCT) evidence of parenchymal opacities. Computed tomography and microCT analysis show abundant small airway obstruction, starting from the fifth generation of airway branching and affecting up to 40–70% of airways. The pathogenesis of BOS remains unclear. It is a multifactorial syndrome that leads to pathological tissue changes and clinical manifestations. Because BOS is associated with the worst long-term survival in LTx patients, many studies are focused on the early identification of BOS. Markers may be useful for diagnosis and for understanding the molecular and immunological mechanisms involved in the onset of BOS. Diagnostic and predictive markers of BOS have also been investigated in various biological materials, such as blood, BAL, lung tissue and extracellular vesicles. The aim of this review was to evaluate the scientific literature on markers of BOS after lung transplant. We performed a systematic review to find all available data on potential prognostic and diagnostic markers of BOS.https://www.mdpi.com/2227-9059/10/12/3277biomarkerslung transplantbronchiolitis obliterans syndrome |
| spellingShingle | Dalila Cavallaro Marco Guerrieri Stefano Cattelan Gaia Fabbri Sara Croce Martina Armati David Bennett Antonella Fossi Luca Voltolini Luca Luzzi Alberto Salvicchi Piero Paladini Adriano Peris Miriana d’Alessandro Paolo Cameli Elena Bargagli Tuscany Transplant Group Laura Bergantini Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective Biomedicines biomarkers lung transplant bronchiolitis obliterans syndrome |
| title | Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective |
| title_full | Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective |
| title_fullStr | Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective |
| title_full_unstemmed | Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective |
| title_short | Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective |
| title_sort | markers of bronchiolitis obliterans syndrome after lung transplant between old knowledge and future perspective |
| topic | biomarkers lung transplant bronchiolitis obliterans syndrome |
| url | https://www.mdpi.com/2227-9059/10/12/3277 |
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