Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach
IntroductionThe influence of pre-existing humoral immunity, inter-individual demographic factors, and vaccine-associated reactogenicity on immunogenicity following COVID vaccination remains poorly understood.MethodsTen-fold cross-validated least absolute shrinkage and selection operator (LASSO) and...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.971277/full |
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| author | Erin C. Williams Alexander Kizhner Valerie S. Stark Aria Nawab Daniel D. Muniz Felipe Echeverri Tribin Juan Manuel Carreño Dominika Bielak Gagandeep Singh Michael E. Hoffer Michael E. Hoffer Florian Krammer Florian Krammer Suresh Pallikkuth Savita Pahwa |
| author_facet | Erin C. Williams Alexander Kizhner Valerie S. Stark Aria Nawab Daniel D. Muniz Felipe Echeverri Tribin Juan Manuel Carreño Dominika Bielak Gagandeep Singh Michael E. Hoffer Michael E. Hoffer Florian Krammer Florian Krammer Suresh Pallikkuth Savita Pahwa |
| author_sort | Erin C. Williams |
| collection | DOAJ |
| description | IntroductionThe influence of pre-existing humoral immunity, inter-individual demographic factors, and vaccine-associated reactogenicity on immunogenicity following COVID vaccination remains poorly understood.MethodsTen-fold cross-validated least absolute shrinkage and selection operator (LASSO) and linear mixed effects models were used to evaluate symptoms experienced by COVID+ participants during natural infection and following SARS-CoV-2 mRNA vaccination along with demographics as predictors for antibody (AB) responses to recombinant spike protein in a longitudinal cohort study.ResultsIn previously infected individuals (n=33), AB were more durable and robust following primary vaccination when compared to natural infection alone. Higher AB were associated with experiencing dyspnea during natural infection, as was the total number of symptoms reported during the COVID-19 disease course. Both local and systemic symptoms following 1st and 2nd dose (n=49 and 48, respectively) of SARS-CoV-2 mRNA vaccines were predictive of higher AB after vaccination. Lastly, there was a significant temporal relationship between AB and days since infection or vaccination, suggesting that vaccination in COVID+ individuals is associated with a more robust immune response.DiscussionExperiencing systemic and local symptoms post-vaccine was suggestive of higher AB, which may confer greater protection. |
| first_indexed | 2024-04-10T16:22:21Z |
| format | Article |
| id | doaj.art-5cd163ee70284d0dab8faaad6d883918 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T16:22:21Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5cd163ee70284d0dab8faaad6d8839182023-02-09T12:08:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.971277971277Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approachErin C. Williams0Alexander Kizhner1Valerie S. Stark2Aria Nawab3Daniel D. Muniz4Felipe Echeverri Tribin5Juan Manuel Carreño6Dominika Bielak7Gagandeep Singh8Michael E. Hoffer9Michael E. Hoffer10Florian Krammer11Florian Krammer12Suresh Pallikkuth13Savita Pahwa14Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Biomedical Engineering, University of Miami, Miami, FL, United StatesDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Neurological Surgery, University of Miami, Miller School of Medicine, Miami, FL, United StatesDepartment of Biomedical Engineering, University of Miami, Miami, FL, United StatesDepartment of Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United StatesIntroductionThe influence of pre-existing humoral immunity, inter-individual demographic factors, and vaccine-associated reactogenicity on immunogenicity following COVID vaccination remains poorly understood.MethodsTen-fold cross-validated least absolute shrinkage and selection operator (LASSO) and linear mixed effects models were used to evaluate symptoms experienced by COVID+ participants during natural infection and following SARS-CoV-2 mRNA vaccination along with demographics as predictors for antibody (AB) responses to recombinant spike protein in a longitudinal cohort study.ResultsIn previously infected individuals (n=33), AB were more durable and robust following primary vaccination when compared to natural infection alone. Higher AB were associated with experiencing dyspnea during natural infection, as was the total number of symptoms reported during the COVID-19 disease course. Both local and systemic symptoms following 1st and 2nd dose (n=49 and 48, respectively) of SARS-CoV-2 mRNA vaccines were predictive of higher AB after vaccination. Lastly, there was a significant temporal relationship between AB and days since infection or vaccination, suggesting that vaccination in COVID+ individuals is associated with a more robust immune response.DiscussionExperiencing systemic and local symptoms post-vaccine was suggestive of higher AB, which may confer greater protection.https://www.frontiersin.org/articles/10.3389/fimmu.2023.971277/fullvaccine reactogenicityinfectionprotective antibodiesCOVID-19SARS-CoV-2 |
| spellingShingle | Erin C. Williams Alexander Kizhner Valerie S. Stark Aria Nawab Daniel D. Muniz Felipe Echeverri Tribin Juan Manuel Carreño Dominika Bielak Gagandeep Singh Michael E. Hoffer Michael E. Hoffer Florian Krammer Florian Krammer Suresh Pallikkuth Savita Pahwa Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach Frontiers in Immunology vaccine reactogenicity infection protective antibodies COVID-19 SARS-CoV-2 |
| title | Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach |
| title_full | Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach |
| title_fullStr | Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach |
| title_full_unstemmed | Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach |
| title_short | Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach |
| title_sort | predictors for reactogenicity and humoral immunity to sars cov 2 following infection and mrna vaccination a regularized mixed effects modelling approach |
| topic | vaccine reactogenicity infection protective antibodies COVID-19 SARS-CoV-2 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.971277/full |
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