Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach

Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach

IntroductionThe influence of pre-existing humoral immunity, inter-individual demographic factors, and vaccine-associated reactogenicity on immunogenicity following COVID vaccination remains poorly understood.MethodsTen-fold cross-validated least absolute shrinkage and selection operator (LASSO) and...

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Bibliographic Details
Main Authors: Erin C. Williams, Alexander Kizhner, Valerie S. Stark, Aria Nawab, Daniel D. Muniz, Felipe Echeverri Tribin, Juan Manuel Carreño, Dominika Bielak, Gagandeep Singh, Michael E. Hoffer, Florian Krammer, Suresh Pallikkuth, Savita Pahwa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
vaccine reactogenicity
infection
protective antibodies
COVID-19
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.971277/full

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