A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity

A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity

In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with 5-(aryl)furfural derivatives. The compounds were evaluated for their in vitro antimic...

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Bibliographic Details
Main Authors:	Ahmet Özdemir, Mehlika Dilek Altıntop, Belgin Sever, Hülya Karaca Gençer, Handan Açelya Kapkaç, Özlem Atlı, Merve Baysal
Format:	Article
Language:	English
Published:	MDPI AG 2017-11-01
Series:	Molecules
Subjects:	antimicrobial activity chalcone cytotoxicity furan genotoxicity pyrrole
Online Access:	https://www.mdpi.com/1420-3049/22/12/2112

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