The Sequence Effect in Parkinson’s Disease
Background and Purpose The sequence effect (SE) in Parkinson’s disease (PD) denotes progressive slowness in speed or progressive decrease in amplitude of repetitive movements. It is a well-known feature of bradykinesia and is considered unique in PD. Until now, it was well-documented in advanced PD,...
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2011-05-01
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| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://e-jmd.org/upload/jmd-4-1-38-6.pdf |
| _version_ | 1827833528063098880 |
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| author | Suk Yun Kang Toshiaki Wasaka Ejaz A. Shamim Sungyoung Auh Yoshino Ueki Nguyet Dang Mark Hallett |
| author_facet | Suk Yun Kang Toshiaki Wasaka Ejaz A. Shamim Sungyoung Auh Yoshino Ueki Nguyet Dang Mark Hallett |
| author_sort | Suk Yun Kang |
| collection | DOAJ |
| description | Background and Purpose The sequence effect (SE) in Parkinson’s disease (PD) denotes progressive slowness in speed or progressive decrease in amplitude of repetitive movements. It is a well-known feature of bradykinesia and is considered unique in PD. Until now, it was well-documented in advanced PD, but not in drug-naïve PD. The aim of this study is to know whether the SE can also be measured in drug-naïve PD. Methods We measured the SE with a computer-based, modified Purdue pegboard in 4 drug-naïve PD patients, which matched our previous study with advanced PD patients. Results We observed progressive slowness during movement, that is, SE. Statistical analysis showed a strong statistical trend toward the SE with the right hand, but no significance with the left hand. There was no statistical significance of SE with either the more or less affected hands. Conclusions These results indicate that the SE can be identified in drug-naïve PD, as well as in advanced PD, with objective measurements and support the idea that the SE is a feature in PD observed during the early stage of the disease without medication. |
| first_indexed | 2024-03-12T05:33:24Z |
| format | Article |
| id | doaj.art-5cd63892ec2a4030b676805e35c81d48 |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T05:33:24Z |
| publishDate | 2011-05-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-5cd63892ec2a4030b676805e35c81d482023-09-03T06:36:43ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392011-05-0141384010.14802/jmd.1100633The Sequence Effect in Parkinson’s DiseaseSuk Yun KangToshiaki WasakaEjaz A. ShamimSungyoung AuhYoshino UekiNguyet DangMark HallettBackground and Purpose The sequence effect (SE) in Parkinson’s disease (PD) denotes progressive slowness in speed or progressive decrease in amplitude of repetitive movements. It is a well-known feature of bradykinesia and is considered unique in PD. Until now, it was well-documented in advanced PD, but not in drug-naïve PD. The aim of this study is to know whether the SE can also be measured in drug-naïve PD. Methods We measured the SE with a computer-based, modified Purdue pegboard in 4 drug-naïve PD patients, which matched our previous study with advanced PD patients. Results We observed progressive slowness during movement, that is, SE. Statistical analysis showed a strong statistical trend toward the SE with the right hand, but no significance with the left hand. There was no statistical significance of SE with either the more or less affected hands. Conclusions These results indicate that the SE can be identified in drug-naïve PD, as well as in advanced PD, with objective measurements and support the idea that the SE is a feature in PD observed during the early stage of the disease without medication.http://e-jmd.org/upload/jmd-4-1-38-6.pdfParkinson’s diseaseBradykinesiaSequence effectProgressive slownessPegboard test |
| spellingShingle | Suk Yun Kang Toshiaki Wasaka Ejaz A. Shamim Sungyoung Auh Yoshino Ueki Nguyet Dang Mark Hallett The Sequence Effect in Parkinson’s Disease Journal of Movement Disorders Parkinson’s disease Bradykinesia Sequence effect Progressive slowness Pegboard test |
| title | The Sequence Effect in Parkinson’s Disease |
| title_full | The Sequence Effect in Parkinson’s Disease |
| title_fullStr | The Sequence Effect in Parkinson’s Disease |
| title_full_unstemmed | The Sequence Effect in Parkinson’s Disease |
| title_short | The Sequence Effect in Parkinson’s Disease |
| title_sort | sequence effect in parkinson s disease |
| topic | Parkinson’s disease Bradykinesia Sequence effect Progressive slowness Pegboard test |
| url | http://e-jmd.org/upload/jmd-4-1-38-6.pdf |
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