Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress
Drug-induced liver injury (DILI) is a serious clinical disease associated with reactive oxygen species (ROS) burst and subsequent inflammatory responses. However, traditional treatments were limited by low efficacy and serious side effects due to the special liver structure. Here, we developed a mol...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1039558/full |
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| author | Yunrong Yang Yunrong Yang Min Liu Min Liu Tianjiao Zhao Tianjiao Zhao Qiaohui Chen Qiaohui Chen Yuqi Yang Yuqi Yang Shuya Wang Shuya Wang Jinping Zhang Jinping Zhang Guiming Deng Kewei Sun Yayun Nan Ke Cao Kelong Ai Kelong Ai Qiong Huang Qiong Huang |
| author_facet | Yunrong Yang Yunrong Yang Min Liu Min Liu Tianjiao Zhao Tianjiao Zhao Qiaohui Chen Qiaohui Chen Yuqi Yang Yuqi Yang Shuya Wang Shuya Wang Jinping Zhang Jinping Zhang Guiming Deng Kewei Sun Yayun Nan Ke Cao Kelong Ai Kelong Ai Qiong Huang Qiong Huang |
| author_sort | Yunrong Yang |
| collection | DOAJ |
| description | Drug-induced liver injury (DILI) is a serious clinical disease associated with reactive oxygen species (ROS) burst and subsequent inflammatory responses. However, traditional treatments were limited by low efficacy and serious side effects due to the special liver structure. Here, we developed a molybdenum (Mo)-based nanoparticles, EGM NPs, after overall consideration of the pathophysiology of DILI and the advantages of nanodrugs. It demonstrated that EGM NPs treated acetaminophen (APAP)-induced DILI by scavenging ROS and inhibiting inflammation. EGM NPs effectively scavenged various ROS and reduced cell apoptosis at the cellular level. More importantly, EGM NPs can treat APAP-induced DILI in vivo, reducing the levels of liver function indicators in mice with liver injury, scaling down the area of hepatocyte necrosis and successfully inhibiting endoplasmic reticulum (ER) stress in the liver. EGM NPs also showed a certain anti-inflammatory effect by reducing infiltration of macrophages, decreasing pro-inflammatory factors and inhibiting the expression levels of inducible nitric oxide synthase (NOS2) and myeloperoxidase (MPO). Collectively, our findings suggest that EGM NPs-based nanotherapeutic is a novel strategy for the treatment of DILI. |
| first_indexed | 2024-04-12T09:33:30Z |
| format | Article |
| id | doaj.art-5cd7c60573bf43589d2c489cd5864ddf |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T09:33:30Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5cd7c60573bf43589d2c489cd5864ddf2022-12-22T03:38:17ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.10395581039558Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stressYunrong Yang0Yunrong Yang1Min Liu2Min Liu3Tianjiao Zhao4Tianjiao Zhao5Qiaohui Chen6Qiaohui Chen7Yuqi Yang8Yuqi Yang9Shuya Wang10Shuya Wang11Jinping Zhang12Jinping Zhang13Guiming Deng14Kewei Sun15Yayun Nan16Ke Cao17Kelong Ai18Kelong Ai19Qiong Huang20Qiong Huang21Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Infection and Liver Disease, The First Hospital of Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Infection and Liver Disease, The First Hospital of Hunan University of Chinese Medicine, Changsha, ChinaGeriatric Medical Center, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, ChinaDepartment of Oncology, The Third Xiangya Hospital, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDrug-induced liver injury (DILI) is a serious clinical disease associated with reactive oxygen species (ROS) burst and subsequent inflammatory responses. However, traditional treatments were limited by low efficacy and serious side effects due to the special liver structure. Here, we developed a molybdenum (Mo)-based nanoparticles, EGM NPs, after overall consideration of the pathophysiology of DILI and the advantages of nanodrugs. It demonstrated that EGM NPs treated acetaminophen (APAP)-induced DILI by scavenging ROS and inhibiting inflammation. EGM NPs effectively scavenged various ROS and reduced cell apoptosis at the cellular level. More importantly, EGM NPs can treat APAP-induced DILI in vivo, reducing the levels of liver function indicators in mice with liver injury, scaling down the area of hepatocyte necrosis and successfully inhibiting endoplasmic reticulum (ER) stress in the liver. EGM NPs also showed a certain anti-inflammatory effect by reducing infiltration of macrophages, decreasing pro-inflammatory factors and inhibiting the expression levels of inducible nitric oxide synthase (NOS2) and myeloperoxidase (MPO). Collectively, our findings suggest that EGM NPs-based nanotherapeutic is a novel strategy for the treatment of DILI.https://www.frontiersin.org/articles/10.3389/fphar.2022.1039558/fullepigallocatechin-3-gallate Mo nanoparticlesreactive oxygen speciesacetaminophendrug-induced liver injuryanti-inflammatoryendoplasmic reticulum stress |
| spellingShingle | Yunrong Yang Yunrong Yang Min Liu Min Liu Tianjiao Zhao Tianjiao Zhao Qiaohui Chen Qiaohui Chen Yuqi Yang Yuqi Yang Shuya Wang Shuya Wang Jinping Zhang Jinping Zhang Guiming Deng Kewei Sun Yayun Nan Ke Cao Kelong Ai Kelong Ai Qiong Huang Qiong Huang Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress Frontiers in Pharmacology epigallocatechin-3-gallate Mo nanoparticles reactive oxygen species acetaminophen drug-induced liver injury anti-inflammatory endoplasmic reticulum stress |
| title | Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress |
| title_full | Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress |
| title_fullStr | Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress |
| title_full_unstemmed | Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress |
| title_short | Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress |
| title_sort | epigallocatechin 3 gallate mo nanoparticles egm nps efficiently treat liver injury by strongly reducing oxidative stress inflammation and endoplasmic reticulum stress |
| topic | epigallocatechin-3-gallate Mo nanoparticles reactive oxygen species acetaminophen drug-induced liver injury anti-inflammatory endoplasmic reticulum stress |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1039558/full |
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