The Role of Interferons in Inflammation and Inflammasome Activation
Inflammation is an essential physiological process, which enables survival during infection and maintains tissue homeostasis. Interferons (IFNs) and pro- and anti-inflammatory cytokines are crucial for appropriate response to pathogens, damaged cells, or irritants in inflammatory response. The infla...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00873/full |
| _version_ | 1828292737876623360 |
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| author | Nataša Kopitar-Jerala |
| author_facet | Nataša Kopitar-Jerala |
| author_sort | Nataša Kopitar-Jerala |
| collection | DOAJ |
| description | Inflammation is an essential physiological process, which enables survival during infection and maintains tissue homeostasis. Interferons (IFNs) and pro- and anti-inflammatory cytokines are crucial for appropriate response to pathogens, damaged cells, or irritants in inflammatory response. The inflammasom is multiprotein complex, which initiates cleavage of pro-inflammatory cytokines IL-1β and IL-18 into active forms. In addition, inflammasomes initiate pyroptotic cell death. In the present review, I summarize and analyze recent findings regarding the cross talk of IFNs and inflammasomes. |
| first_indexed | 2024-04-13T11:13:19Z |
| format | Article |
| id | doaj.art-5cd801e95c6c43fe84789b4cfe294334 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T11:13:19Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5cd801e95c6c43fe84789b4cfe2943342022-12-22T02:49:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-07-01810.3389/fimmu.2017.00873263291The Role of Interferons in Inflammation and Inflammasome ActivationNataša Kopitar-Jerala0Department of Biochemistry, Molecular and Structural Biology, Jožef Stefan Institute, Ljubljana, SloveniaInflammation is an essential physiological process, which enables survival during infection and maintains tissue homeostasis. Interferons (IFNs) and pro- and anti-inflammatory cytokines are crucial for appropriate response to pathogens, damaged cells, or irritants in inflammatory response. The inflammasom is multiprotein complex, which initiates cleavage of pro-inflammatory cytokines IL-1β and IL-18 into active forms. In addition, inflammasomes initiate pyroptotic cell death. In the present review, I summarize and analyze recent findings regarding the cross talk of IFNs and inflammasomes.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00873/fullcaspase-1caspase-11cyclic GMP-AMP synthaseguanylate-binding proteininterferoninflammasome |
| spellingShingle | Nataša Kopitar-Jerala The Role of Interferons in Inflammation and Inflammasome Activation Frontiers in Immunology caspase-1 caspase-11 cyclic GMP-AMP synthase guanylate-binding protein interferon inflammasome |
| title | The Role of Interferons in Inflammation and Inflammasome Activation |
| title_full | The Role of Interferons in Inflammation and Inflammasome Activation |
| title_fullStr | The Role of Interferons in Inflammation and Inflammasome Activation |
| title_full_unstemmed | The Role of Interferons in Inflammation and Inflammasome Activation |
| title_short | The Role of Interferons in Inflammation and Inflammasome Activation |
| title_sort | role of interferons in inflammation and inflammasome activation |
| topic | caspase-1 caspase-11 cyclic GMP-AMP synthase guanylate-binding protein interferon inflammasome |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00873/full |
| work_keys_str_mv | AT natasakopitarjerala theroleofinterferonsininflammationandinflammasomeactivation AT natasakopitarjerala roleofinterferonsininflammationandinflammasomeactivation |