Analysis of the contribution of <it>FTO</it>, <it>NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes to obesity in Mexican children
<p>Abstract</p> <p>Background</p> <p>Recent genome wide association studies (GWAS) and previous positional linkage studies have identified more than 50 single nucleotide polymorphisms (SNPs) associated with obesity, mostly in Europeans. We aimed to assess the contributi...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2013-02-01
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| Series: | BMC Medical Genetics |
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| Online Access: | http://www.biomedcentral.com/1471-2350/14/21 |
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| author | Mejía-Benítez Aurora Klünder-Klünder Miguel Yengo Loic Meyre David Aradillas Celia Cruz Esperanza Pérez-Luque Elva Malacara Juan Manuel Garay Maria Eugenia Peralta-Romero Jesús Flores-Huerta Samuel García-Mena Jaime Froguel Philippe Cruz Miguel Bonnefond Amélie |
| author_facet | Mejía-Benítez Aurora Klünder-Klünder Miguel Yengo Loic Meyre David Aradillas Celia Cruz Esperanza Pérez-Luque Elva Malacara Juan Manuel Garay Maria Eugenia Peralta-Romero Jesús Flores-Huerta Samuel García-Mena Jaime Froguel Philippe Cruz Miguel Bonnefond Amélie |
| author_sort | Mejía-Benítez Aurora |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recent genome wide association studies (GWAS) and previous positional linkage studies have identified more than 50 single nucleotide polymorphisms (SNPs) associated with obesity, mostly in Europeans. We aimed to assess the contribution of some of these SNPs to obesity risk and to the variation of related metabolic traits, in Mexican children.</p> <p>Methods</p> <p>The association of six European obesity-related SNPs in or near <it>FTO, NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes with risk of obesity was tested in 1,463 school-aged Mexican children (<it>N</it><sub><it>cases</it></sub> = 514; <it>N</it><sub><it>controls</it></sub> = 949). We also assessed effects of these SNPs on the variation of body mass index (BMI), fasting serum insulin levels, fasting plasma glucose levels, total cholesterol and triglyceride levels, in a subset of 1,171 nonobese Mexican children.</p> <p>Results</p> <p>We found a significant effect of <it>GNPDA2</it> rs10938397 on risk of obesity (odds ratio [OR] = 1.30; <it>P</it> = 1.34 × 10<sup>-3</sup>). Furthermore, we found nominal associations between obesity risk or BMI variation and the following SNPs: <it>ENPP1</it> rs7754561, <it>MC4R</it> rs17782313 and <it>NEGR1</it> rs2815752. Importantly, the at-risk alleles of both <it>MC4R</it> rs17782313 and <it>NPC1</it> rs1805081 showed significant effect on increased fasting glucose levels (β = 0.36 mmol/L; <it>P</it> = 1.47 × 10<sup>-3</sup>) and decreased fasting serum insulin levels (β = −0.10 μU/mL; <it>P</it> = 1.21 × 10<sup>-3</sup>), respectively.</p> <p>Conclusion</p> <p>Our present results suggest that some obesity-associated SNPs previously reported in Europeans also associate with risk of obesity, or metabolic quantitative traits, in Mexican children. Importantly, we found new associations between <it>MC4R</it> and fasting glucose levels, and between <it>NPC1</it> and fasting insulin levels.</p> |
| first_indexed | 2024-12-13T23:46:33Z |
| format | Article |
| id | doaj.art-5cd8bb86a3814464af95be35b2be4e50 |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-13T23:46:33Z |
| publishDate | 2013-02-01 |
| publisher | BMC |
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| series | BMC Medical Genetics |
| spelling | doaj.art-5cd8bb86a3814464af95be35b2be4e502022-12-21T23:26:57ZengBMCBMC Medical Genetics1471-23502013-02-011412110.1186/1471-2350-14-21Analysis of the contribution of <it>FTO</it>, <it>NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes to obesity in Mexican childrenMejía-Benítez AuroraKlünder-Klünder MiguelYengo LoicMeyre DavidAradillas CeliaCruz EsperanzaPérez-Luque ElvaMalacara Juan ManuelGaray Maria EugeniaPeralta-Romero JesúsFlores-Huerta SamuelGarcía-Mena JaimeFroguel PhilippeCruz MiguelBonnefond Amélie<p>Abstract</p> <p>Background</p> <p>Recent genome wide association studies (GWAS) and previous positional linkage studies have identified more than 50 single nucleotide polymorphisms (SNPs) associated with obesity, mostly in Europeans. We aimed to assess the contribution of some of these SNPs to obesity risk and to the variation of related metabolic traits, in Mexican children.</p> <p>Methods</p> <p>The association of six European obesity-related SNPs in or near <it>FTO, NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes with risk of obesity was tested in 1,463 school-aged Mexican children (<it>N</it><sub><it>cases</it></sub> = 514; <it>N</it><sub><it>controls</it></sub> = 949). We also assessed effects of these SNPs on the variation of body mass index (BMI), fasting serum insulin levels, fasting plasma glucose levels, total cholesterol and triglyceride levels, in a subset of 1,171 nonobese Mexican children.</p> <p>Results</p> <p>We found a significant effect of <it>GNPDA2</it> rs10938397 on risk of obesity (odds ratio [OR] = 1.30; <it>P</it> = 1.34 × 10<sup>-3</sup>). Furthermore, we found nominal associations between obesity risk or BMI variation and the following SNPs: <it>ENPP1</it> rs7754561, <it>MC4R</it> rs17782313 and <it>NEGR1</it> rs2815752. Importantly, the at-risk alleles of both <it>MC4R</it> rs17782313 and <it>NPC1</it> rs1805081 showed significant effect on increased fasting glucose levels (β = 0.36 mmol/L; <it>P</it> = 1.47 × 10<sup>-3</sup>) and decreased fasting serum insulin levels (β = −0.10 μU/mL; <it>P</it> = 1.21 × 10<sup>-3</sup>), respectively.</p> <p>Conclusion</p> <p>Our present results suggest that some obesity-associated SNPs previously reported in Europeans also associate with risk of obesity, or metabolic quantitative traits, in Mexican children. Importantly, we found new associations between <it>MC4R</it> and fasting glucose levels, and between <it>NPC1</it> and fasting insulin levels.</p>http://www.biomedcentral.com/1471-2350/14/21ObesityMexican childrenSingle nucleotide polymorphism |
| spellingShingle | Mejía-Benítez Aurora Klünder-Klünder Miguel Yengo Loic Meyre David Aradillas Celia Cruz Esperanza Pérez-Luque Elva Malacara Juan Manuel Garay Maria Eugenia Peralta-Romero Jesús Flores-Huerta Samuel García-Mena Jaime Froguel Philippe Cruz Miguel Bonnefond Amélie Analysis of the contribution of <it>FTO</it>, <it>NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes to obesity in Mexican children BMC Medical Genetics Obesity Mexican children Single nucleotide polymorphism |
| title | Analysis of the contribution of <it>FTO</it>, <it>NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes to obesity in Mexican children |
| title_full | Analysis of the contribution of <it>FTO</it>, <it>NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes to obesity in Mexican children |
| title_fullStr | Analysis of the contribution of <it>FTO</it>, <it>NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes to obesity in Mexican children |
| title_full_unstemmed | Analysis of the contribution of <it>FTO</it>, <it>NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes to obesity in Mexican children |
| title_short | Analysis of the contribution of <it>FTO</it>, <it>NPC1, ENPP1, NEGR1, GNPDA2</it> and <it>MC4R</it> genes to obesity in Mexican children |
| title_sort | analysis of the contribution of it fto it it npc1 enpp1 negr1 gnpda2 it and it mc4r it genes to obesity in mexican children |
| topic | Obesity Mexican children Single nucleotide polymorphism |
| url | http://www.biomedcentral.com/1471-2350/14/21 |
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