Extracellular vesicles in cardiomyopathies: A narrative review
Extracellular vesicles (EVs) are membrane-bound particles released by all cells under physiological and pathological conditions. EVs constitute a potential tool to unravel cell-specific pathophysiological mechanisms at the root of disease states and retain the potential to act as biomarkers for card...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402310973X |
| _version_ | 1797336960430243840 |
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| author | A.S. Rizzuto A. Faggiano C. Macchi S. Carugo C. Perrino M. Ruscica |
| author_facet | A.S. Rizzuto A. Faggiano C. Macchi S. Carugo C. Perrino M. Ruscica |
| author_sort | A.S. Rizzuto |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are membrane-bound particles released by all cells under physiological and pathological conditions. EVs constitute a potential tool to unravel cell-specific pathophysiological mechanisms at the root of disease states and retain the potential to act as biomarkers for cardiac diseases. By being able to carry bioactive cargo (such as proteins and miRNAs), EVs harness great potential as accessible “liquid biopsies”, given their ability to reflect the state of their cell of origin. Cardiomyopathies encompass a variety of myocardial disorders associated with mechanical, functional and/or electric dysfunction. These diseases exhibit different phenotypes, including inappropriate ventricular hypertrophy, dilatation, scarring, fibro-fatty replacement, dysfunction, and may stem from multiple aetiologies, most often genetic. Thus, the aims of this narrative review are to summarize the current knowledge on EVs and cardiomyopathies (e.g., hypertrophic, dilated and arrhythmogenic), to elucidate the potential role of EVs in the paracrine cell-to-cell communication among cardiac tissue compartments, in aiding the diagnosis of the diverse subtypes of cardiomyopathies in a minimally invasive manner, and finally to address whether certain molecular and phenotypical characteristics of EVs may correlate with cardiomyopathy disease phenotype and severity. |
| first_indexed | 2024-03-08T09:02:27Z |
| format | Article |
| id | doaj.art-5cd9e5f6aa8446a7a34158e7183275af |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:02:27Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-5cd9e5f6aa8446a7a34158e7183275af2024-02-01T06:33:26ZengElsevierHeliyon2405-84402024-01-01101e23765Extracellular vesicles in cardiomyopathies: A narrative reviewA.S. Rizzuto0A. Faggiano1C. Macchi2S. Carugo3C. Perrino4M. Ruscica5Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy; Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Cà Granda Ospedale Maggiore Policlinico, ItalyDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Università degli Studi di Milano, Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy; Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Cà Granda Ospedale Maggiore Policlinico, ItalyDepartment of Advanced Biomedical Sciences, Federico II University, 80131, Naples, ItalyDepartment of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Cà Granda Ospedale Maggiore Policlinico, Italy; Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Università degli Studi di Milano, Milan, Italy; Corresponding author. Department of Pharmacological and Biomolecular Sciences ''Rodolfo Paoletti'', Università degli Studi di Milano, Milan, Italy.Extracellular vesicles (EVs) are membrane-bound particles released by all cells under physiological and pathological conditions. EVs constitute a potential tool to unravel cell-specific pathophysiological mechanisms at the root of disease states and retain the potential to act as biomarkers for cardiac diseases. By being able to carry bioactive cargo (such as proteins and miRNAs), EVs harness great potential as accessible “liquid biopsies”, given their ability to reflect the state of their cell of origin. Cardiomyopathies encompass a variety of myocardial disorders associated with mechanical, functional and/or electric dysfunction. These diseases exhibit different phenotypes, including inappropriate ventricular hypertrophy, dilatation, scarring, fibro-fatty replacement, dysfunction, and may stem from multiple aetiologies, most often genetic. Thus, the aims of this narrative review are to summarize the current knowledge on EVs and cardiomyopathies (e.g., hypertrophic, dilated and arrhythmogenic), to elucidate the potential role of EVs in the paracrine cell-to-cell communication among cardiac tissue compartments, in aiding the diagnosis of the diverse subtypes of cardiomyopathies in a minimally invasive manner, and finally to address whether certain molecular and phenotypical characteristics of EVs may correlate with cardiomyopathy disease phenotype and severity.http://www.sciencedirect.com/science/article/pii/S240584402310973XExtracellular vesiclesCardiomyopathiesHypertrophic cardiomyopathyDilated cardiomyopathyArrhythmogenic cardiomyopathy |
| spellingShingle | A.S. Rizzuto A. Faggiano C. Macchi S. Carugo C. Perrino M. Ruscica Extracellular vesicles in cardiomyopathies: A narrative review Heliyon Extracellular vesicles Cardiomyopathies Hypertrophic cardiomyopathy Dilated cardiomyopathy Arrhythmogenic cardiomyopathy |
| title | Extracellular vesicles in cardiomyopathies: A narrative review |
| title_full | Extracellular vesicles in cardiomyopathies: A narrative review |
| title_fullStr | Extracellular vesicles in cardiomyopathies: A narrative review |
| title_full_unstemmed | Extracellular vesicles in cardiomyopathies: A narrative review |
| title_short | Extracellular vesicles in cardiomyopathies: A narrative review |
| title_sort | extracellular vesicles in cardiomyopathies a narrative review |
| topic | Extracellular vesicles Cardiomyopathies Hypertrophic cardiomyopathy Dilated cardiomyopathy Arrhythmogenic cardiomyopathy |
| url | http://www.sciencedirect.com/science/article/pii/S240584402310973X |
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