Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases
Chronic Schistosoma mansoni infection leads to a type 2-immune response with increased production of interleukin (IL-10). Evidence indicates chronic exposure to S. mansoni down regulates the type 1 immune response and prevents the onset of Th1-mediated diseases such as multiple sclerosis, diabetes m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2004-08-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900005 |
| _version_ | 1797702968739364864 |
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| author | Maria Ilma Araújo Bradford S Hoppe Manoel Medeiros Jr Edgar M Carvalho |
| author_facet | Maria Ilma Araújo Bradford S Hoppe Manoel Medeiros Jr Edgar M Carvalho |
| author_sort | Maria Ilma Araújo |
| collection | DOAJ |
| description | Chronic Schistosoma mansoni infection leads to a type 2-immune response with increased production of interleukin (IL-10). Evidence indicates chronic exposure to S. mansoni down regulates the type 1 immune response and prevents the onset of Th1-mediated diseases such as multiple sclerosis, diabetes mellitus and Cronh's disease. Furthermore, our own studies have revealed that chronic exposure to S. mansoni also down regulates atopic disease, Th2-mediated diseases. Our studies show an inverse association between the skin prick test reactivity and infection with S. mansoni and show the severity of asthma is reduced in subjects living in an endemic area of S. mansoni. Moreover, we hypothesize the mechanisms involved in the modulation of inflammatory response in atopic individuals, is likely dependent on IL-10 production, an anti-inflammatory cytokine elevated during helminth infections. Patients with asthma and helminth infections produced less IL-5 than patients with asthma without helminth infections, and this down regulation could, in part, be mediated by IL-10. In conclusion, helminthic infections, through induction of regulatory mechanisms, such as IL-10 production, are able to modulate the inflammatory immune response involved in the pathology of auto-immune and allergic disease. |
| first_indexed | 2024-03-12T04:57:39Z |
| format | Article |
| id | doaj.art-5cda47375f4d4b1bb4c7e06134c28d6d |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T04:57:39Z |
| publishDate | 2004-08-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-5cda47375f4d4b1bb4c7e06134c28d6d2023-09-03T09:14:40ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602004-08-0199273210.1590/S0074-02762004000900005Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseasesMaria Ilma AraújoBradford S HoppeManoel Medeiros JrEdgar M CarvalhoChronic Schistosoma mansoni infection leads to a type 2-immune response with increased production of interleukin (IL-10). Evidence indicates chronic exposure to S. mansoni down regulates the type 1 immune response and prevents the onset of Th1-mediated diseases such as multiple sclerosis, diabetes mellitus and Cronh's disease. Furthermore, our own studies have revealed that chronic exposure to S. mansoni also down regulates atopic disease, Th2-mediated diseases. Our studies show an inverse association between the skin prick test reactivity and infection with S. mansoni and show the severity of asthma is reduced in subjects living in an endemic area of S. mansoni. Moreover, we hypothesize the mechanisms involved in the modulation of inflammatory response in atopic individuals, is likely dependent on IL-10 production, an anti-inflammatory cytokine elevated during helminth infections. Patients with asthma and helminth infections produced less IL-5 than patients with asthma without helminth infections, and this down regulation could, in part, be mediated by IL-10. In conclusion, helminthic infections, through induction of regulatory mechanisms, such as IL-10 production, are able to modulate the inflammatory immune response involved in the pathology of auto-immune and allergic disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900005Schistosoma mansonialergic diseaseasthmaauto-immune diseases |
| spellingShingle | Maria Ilma Araújo Bradford S Hoppe Manoel Medeiros Jr Edgar M Carvalho Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases Memorias do Instituto Oswaldo Cruz Schistosoma mansoni alergic disease asthma auto-immune diseases |
| title | Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases |
| title_full | Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases |
| title_fullStr | Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases |
| title_full_unstemmed | Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases |
| title_short | Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases |
| title_sort | schistosoma mansoni infection modulates the immune response against allergic and auto immune diseases |
| topic | Schistosoma mansoni alergic disease asthma auto-immune diseases |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900005 |
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