The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer
The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-12-01
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| Series: | Molecular Therapy: Oncolytics |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770519300786 |
| _version_ | 1828487530721312768 |
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| author | Xiaoming Zhong Bin Chen Min Liu Zhiwen Yang |
| author_facet | Xiaoming Zhong Bin Chen Min Liu Zhiwen Yang |
| author_sort | Xiaoming Zhong |
| collection | DOAJ |
| description | The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of colitis-associated colorectal cancer (CAC). This review summarizes the current understanding of CARD9 functions in CAC, and we discuss its potentially carcinogenic mechanisms. Keywords: CARD9, colitis-associated cancer, myeloid-derived suppressor cells, inflammasome activation, IL-22, STAT3 |
| first_indexed | 2024-12-11T09:52:20Z |
| format | Article |
| id | doaj.art-5cda9af04f7c475d9862ced0594e00b6 |
| institution | Directory Open Access Journal |
| issn | 2372-7705 |
| language | English |
| last_indexed | 2024-12-11T09:52:20Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncolytics |
| spelling | doaj.art-5cda9af04f7c475d9862ced0594e00b62022-12-22T01:12:22ZengElsevierMolecular Therapy: Oncolytics2372-77052019-12-011516The Role of Adaptor Protein CARD9 in Colitis-Associated CancerXiaoming Zhong0Bin Chen1Min Liu2Zhiwen Yang3Jiangxi Province Tumor Hospital, Nanchang, ChinaDepartment of Surgery, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaDepartment of Surgery, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaDepartment of Pharmacy, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai 201600, China; Corresponding author: Zhiwen Yang, Department of Pharmacy, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai 201600, China.The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of colitis-associated colorectal cancer (CAC). This review summarizes the current understanding of CARD9 functions in CAC, and we discuss its potentially carcinogenic mechanisms. Keywords: CARD9, colitis-associated cancer, myeloid-derived suppressor cells, inflammasome activation, IL-22, STAT3http://www.sciencedirect.com/science/article/pii/S2372770519300786 |
| spellingShingle | Xiaoming Zhong Bin Chen Min Liu Zhiwen Yang The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer Molecular Therapy: Oncolytics |
| title | The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer |
| title_full | The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer |
| title_fullStr | The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer |
| title_full_unstemmed | The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer |
| title_short | The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer |
| title_sort | role of adaptor protein card9 in colitis associated cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2372770519300786 |
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