The features of high-risk human papillomavirus infection in different female genital sites and impacts on HPV-based cervical cancer screening
Abstract Background The causal role of high-risk Human papillomavirus (HR-HPV) in the pathogenesis of anogenital cancers is well established. In contrast, information on HR-HPV distribution of continuous anatomic sites within the female genital tract is limited, and the impact of sample type on the...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-023-02073-4 |
| _version_ | 1797806844155002880 |
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| author | Tingyuan Li Simiao Chen Xinyue Li Zeni Wu Yuqian Zhao Jianfeng Cui Bin Liu Feng Chen Xun Zhang Youlin Qiao Wen Chen |
| author_facet | Tingyuan Li Simiao Chen Xinyue Li Zeni Wu Yuqian Zhao Jianfeng Cui Bin Liu Feng Chen Xun Zhang Youlin Qiao Wen Chen |
| author_sort | Tingyuan Li |
| collection | DOAJ |
| description | Abstract Background The causal role of high-risk Human papillomavirus (HR-HPV) in the pathogenesis of anogenital cancers is well established. In contrast, information on HR-HPV distribution of continuous anatomic sites within the female genital tract is limited, and the impact of sample type on the clinical performance in HPV-based cervical cancer screening warrants investigation. Methods A total of 2,646 Chinese women were enrolled in the study from May 2006 to April 2007. We analyzed the infection features by infection status and pathological diagnoses of 489 women with complete HR-HPV type and viral load data on the cervix, upper vagina, lower vagina, and perineum samples. Additionally, we assessed the clinical performance for detecting high-grade cervical intraepithelial neoplasia of grade two or worse (≥ CIN2) among these four types of samples. Results HR-HPV positivity rate was lower in the cervix (51.53%) and perineum (55.83%), higher in the upper (65.64%) and lower vagina (64.42%), and increased with the severity of cervical histological lesions (all P<0.001). Single infection was more dominant than multiple infections at each anatomic site of the female genital tract. The proportion of single HR-HPV infection decreased successively from the cervix (67.05%) to the perineum (50.00%) (P trend =0.019) in cervical intraepithelial neoplasia grade 1 (CIN1) and was higher in samples of the cervix (85.11%) and perineum (72.34%) in ≥ CIN2. In addition, the highest viral load was observed in the cervix compared to the other three sites. The overall agreement of the cervical and perineum samples was 79.35% and increased continuously from normal (76.55%) to ≥ CIN2 (91.49%). As for the detection of ≥ CIN2, the sensitivity was 100.00%, 97.87%, 95.74%, and 91.49% for the cervix, upper vagina, lower vagina, and perineum samples, respectively. Conclusions Single HR-HPV infection predominated throughout the female genital tract, but the viral load was lower compared to multiple HR-HPV infections. Despite the decreasing viral load from cervix to perineum, the clinical performance for detecting ≥ CIN2 of the perineum sample was comparable to that of the cervix. |
| first_indexed | 2024-03-13T06:13:31Z |
| format | Article |
| id | doaj.art-5cdb70a06a6340f693a6a9c7199b1b9d |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-03-13T06:13:31Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-5cdb70a06a6340f693a6a9c7199b1b9d2023-06-11T11:05:51ZengBMCVirology Journal1743-422X2023-06-012011910.1186/s12985-023-02073-4The features of high-risk human papillomavirus infection in different female genital sites and impacts on HPV-based cervical cancer screeningTingyuan Li0Simiao Chen1Xinyue Li2Zeni Wu3Yuqian Zhao4Jianfeng Cui5Bin Liu6Feng Chen7Xun Zhang8Youlin Qiao9Wen Chen10Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCollege of Life Sciences, Institute of Life Science and Green Development, Hebei UniversityDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeSichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of ChinaDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Background The causal role of high-risk Human papillomavirus (HR-HPV) in the pathogenesis of anogenital cancers is well established. In contrast, information on HR-HPV distribution of continuous anatomic sites within the female genital tract is limited, and the impact of sample type on the clinical performance in HPV-based cervical cancer screening warrants investigation. Methods A total of 2,646 Chinese women were enrolled in the study from May 2006 to April 2007. We analyzed the infection features by infection status and pathological diagnoses of 489 women with complete HR-HPV type and viral load data on the cervix, upper vagina, lower vagina, and perineum samples. Additionally, we assessed the clinical performance for detecting high-grade cervical intraepithelial neoplasia of grade two or worse (≥ CIN2) among these four types of samples. Results HR-HPV positivity rate was lower in the cervix (51.53%) and perineum (55.83%), higher in the upper (65.64%) and lower vagina (64.42%), and increased with the severity of cervical histological lesions (all P<0.001). Single infection was more dominant than multiple infections at each anatomic site of the female genital tract. The proportion of single HR-HPV infection decreased successively from the cervix (67.05%) to the perineum (50.00%) (P trend =0.019) in cervical intraepithelial neoplasia grade 1 (CIN1) and was higher in samples of the cervix (85.11%) and perineum (72.34%) in ≥ CIN2. In addition, the highest viral load was observed in the cervix compared to the other three sites. The overall agreement of the cervical and perineum samples was 79.35% and increased continuously from normal (76.55%) to ≥ CIN2 (91.49%). As for the detection of ≥ CIN2, the sensitivity was 100.00%, 97.87%, 95.74%, and 91.49% for the cervix, upper vagina, lower vagina, and perineum samples, respectively. Conclusions Single HR-HPV infection predominated throughout the female genital tract, but the viral load was lower compared to multiple HR-HPV infections. Despite the decreasing viral load from cervix to perineum, the clinical performance for detecting ≥ CIN2 of the perineum sample was comparable to that of the cervix.https://doi.org/10.1186/s12985-023-02073-4Human papillomavirusFemale genital tractViral loadCervical cancer |
| spellingShingle | Tingyuan Li Simiao Chen Xinyue Li Zeni Wu Yuqian Zhao Jianfeng Cui Bin Liu Feng Chen Xun Zhang Youlin Qiao Wen Chen The features of high-risk human papillomavirus infection in different female genital sites and impacts on HPV-based cervical cancer screening Virology Journal Human papillomavirus Female genital tract Viral load Cervical cancer |
| title | The features of high-risk human papillomavirus infection in different female genital sites and impacts on HPV-based cervical cancer screening |
| title_full | The features of high-risk human papillomavirus infection in different female genital sites and impacts on HPV-based cervical cancer screening |
| title_fullStr | The features of high-risk human papillomavirus infection in different female genital sites and impacts on HPV-based cervical cancer screening |
| title_full_unstemmed | The features of high-risk human papillomavirus infection in different female genital sites and impacts on HPV-based cervical cancer screening |
| title_short | The features of high-risk human papillomavirus infection in different female genital sites and impacts on HPV-based cervical cancer screening |
| title_sort | features of high risk human papillomavirus infection in different female genital sites and impacts on hpv based cervical cancer screening |
| topic | Human papillomavirus Female genital tract Viral load Cervical cancer |
| url | https://doi.org/10.1186/s12985-023-02073-4 |
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