TLR9 Negatively Regulates Intracellular Bacterial Killing by Pyroptosis in Burkholderia pseudomallei-Infected Mouse Macrophage Cell Line (Raw264.7)

TLR9 Negatively Regulates Intracellular Bacterial Killing by Pyroptosis in Burkholderia pseudomallei-Infected Mouse Macrophage Cell Line (Raw264.7)

ABSTRACT Melioidosis is a serious infectious disease caused by Burkholderia pseudomallei. This bacterium is able to survive and multiply inside the immune cells such as macrophages. It is well established that Toll-like receptors (TLRs), particularly surface TLRs such as TLR2, TLR4, and TLR5, play a...

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Bibliographic Details
Main Authors: Matsayapan Pudla, Sucharat Sanongkiet, Peeraya Ekchariyawat, Chularat Luangjindarat, Marisa Ponpuak, Pongsak Utaisincharoen
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
Burkholderia pseudomallei
caspase-11
macrophage defense
pyroptosis
TLR9
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03488-22

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