Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level
Introduction: End-stage renal disease (ESRD) is associated with critical kidney illness that seriously affects the lifespan. Genetic factors and oxidative stress could play critical role in the development of ESRD. We assessed the association between chemerin rs17173608 T/G and vaspin rs2236242 T/A...
| Váldodahkkit: | , , , , , |
|---|---|
| Materiálatiipa: | Artihkal |
| Giella: | English |
| Almmustuhtton: |
Taylor & Francis Group
2018-10-01
|
| Ráidu: | Renal Failure |
| Fáttát: | |
| Liŋkkat: | http://dx.doi.org/10.1080/0886022X.2018.1459698 |
| _version_ | 1828792117302919168 |
|---|---|
| author | Hamid Nomani Hamid Khanmohamadian Asad Vaisi-Raygani Ebrahim Shakiba Maryam Tanhapour Zohreh Rahimi |
| author_facet | Hamid Nomani Hamid Khanmohamadian Asad Vaisi-Raygani Ebrahim Shakiba Maryam Tanhapour Zohreh Rahimi |
| author_sort | Hamid Nomani |
| collection | DOAJ |
| description | Introduction: End-stage renal disease (ESRD) is associated with critical kidney illness that seriously affects the lifespan. Genetic factors and oxidative stress could play critical role in the development of ESRD. We assessed the association between chemerin rs17173608 T/G and vaspin rs2236242 T/A genes variants with the risk of ESRD and their correlation with plasma malondialdehyde (MDA) level. Materials and methods: In a case-control study, 131 gender and age-matched unrelated healthy controls and 110 ESRD patients were enrolled. The chemerin rs17173608 T/G and vaspin rs2236242 T/A were detected by Tetra primer-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The MDA concentration was determined by HPLC. Results: Our findings for the first time revealed that in codominant genetic model (T/G vs. T/T genotype), the T/G genotype of chemerin gene significantly had a protective role against ESRD susceptibility. Also, in the presence of chemerin G allele, the risk of ESRD decreased by 0.79-fold (p = .048) in Kurdish population of Iran. The MDA serum levels in ESRD patients carrying the chemerin T/G + G/G genotype of rs17173608 T/G and also in carriers of A/A + T/A genotype of vaspin rs2236242 T/A were significantly higher compared to those in control subjects. The overall distribution of vaspin rs2236242 T/A genotypes and alleles comparing ESRD patients and healthy subjects were not statistically significant. Conclusion: We found that the G allele of chemerin rs17173608 compared to T allele decreased the risk of ESRD, and there was a significant association between chemerin and vaspin variants with plasma MDA level in a sample of the Iranian population. |
| first_indexed | 2024-12-12T03:02:31Z |
| format | Article |
| id | doaj.art-5cde9cdb34e84cd98a2bc340f61dea2c |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-12T03:02:31Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-5cde9cdb34e84cd98a2bc340f61dea2c2022-12-22T00:40:35ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492018-10-0140135035610.1080/0886022X.2018.14596981459698Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) levelHamid Nomani0Hamid Khanmohamadian1Asad Vaisi-Raygani2Ebrahim Shakiba3Maryam Tanhapour4Zohreh Rahimi5Kermanshah University of Medical SciencesKermanshah University of Medical SciencesKermanshah University of Medical SciencesKermanshah University of Medical SciencesKermanshah University of Medical SciencesKermanshah University of Medical SciencesIntroduction: End-stage renal disease (ESRD) is associated with critical kidney illness that seriously affects the lifespan. Genetic factors and oxidative stress could play critical role in the development of ESRD. We assessed the association between chemerin rs17173608 T/G and vaspin rs2236242 T/A genes variants with the risk of ESRD and their correlation with plasma malondialdehyde (MDA) level. Materials and methods: In a case-control study, 131 gender and age-matched unrelated healthy controls and 110 ESRD patients were enrolled. The chemerin rs17173608 T/G and vaspin rs2236242 T/A were detected by Tetra primer-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The MDA concentration was determined by HPLC. Results: Our findings for the first time revealed that in codominant genetic model (T/G vs. T/T genotype), the T/G genotype of chemerin gene significantly had a protective role against ESRD susceptibility. Also, in the presence of chemerin G allele, the risk of ESRD decreased by 0.79-fold (p = .048) in Kurdish population of Iran. The MDA serum levels in ESRD patients carrying the chemerin T/G + G/G genotype of rs17173608 T/G and also in carriers of A/A + T/A genotype of vaspin rs2236242 T/A were significantly higher compared to those in control subjects. The overall distribution of vaspin rs2236242 T/A genotypes and alleles comparing ESRD patients and healthy subjects were not statistically significant. Conclusion: We found that the G allele of chemerin rs17173608 compared to T allele decreased the risk of ESRD, and there was a significant association between chemerin and vaspin variants with plasma MDA level in a sample of the Iranian population.http://dx.doi.org/10.1080/0886022X.2018.1459698End-stage renal diseasechemerinvaspinsingle nucleotide polymorphismtetra primer-ARMS-PCRmalondialdehyde (MDA)oxidative stress |
| spellingShingle | Hamid Nomani Hamid Khanmohamadian Asad Vaisi-Raygani Ebrahim Shakiba Maryam Tanhapour Zohreh Rahimi Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level Renal Failure End-stage renal disease chemerin vaspin single nucleotide polymorphism tetra primer-ARMS-PCR malondialdehyde (MDA) oxidative stress |
| title | Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level |
| title_full | Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level |
| title_fullStr | Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level |
| title_full_unstemmed | Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level |
| title_short | Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level |
| title_sort | chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease esrd and correlation with plasma malondialdehyde mda level |
| topic | End-stage renal disease chemerin vaspin single nucleotide polymorphism tetra primer-ARMS-PCR malondialdehyde (MDA) oxidative stress |
| url | http://dx.doi.org/10.1080/0886022X.2018.1459698 |
| work_keys_str_mv | AT hamidnomani chemerinrs17173608andvaspinrs2236242genevariantsontheriskofendstagerenaldiseaseesrdandcorrelationwithplasmamalondialdehydemdalevel AT hamidkhanmohamadian chemerinrs17173608andvaspinrs2236242genevariantsontheriskofendstagerenaldiseaseesrdandcorrelationwithplasmamalondialdehydemdalevel AT asadvaisiraygani chemerinrs17173608andvaspinrs2236242genevariantsontheriskofendstagerenaldiseaseesrdandcorrelationwithplasmamalondialdehydemdalevel AT ebrahimshakiba chemerinrs17173608andvaspinrs2236242genevariantsontheriskofendstagerenaldiseaseesrdandcorrelationwithplasmamalondialdehydemdalevel AT maryamtanhapour chemerinrs17173608andvaspinrs2236242genevariantsontheriskofendstagerenaldiseaseesrdandcorrelationwithplasmamalondialdehydemdalevel AT zohrehrahimi chemerinrs17173608andvaspinrs2236242genevariantsontheriskofendstagerenaldiseaseesrdandcorrelationwithplasmamalondialdehydemdalevel |