PQM130, a Novel Feruloyl–Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer’s Disease

PQM130, a Novel Feruloyl–Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is the most frequent type of dementia in older people. The complex nature of AD calls for the development of multitarget agents addressing key pathogenic processes. Donepezil, an acetylcholinesterase inhibitor, is a first-line acetylcholinesterase inhibitor used for the trea...

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Bibliographic Details
Main Authors: Fabiana Morroni, Giulia Sita, Agnese Graziosi, Gloria Ravegnini, Raffaella Molteni, Maria Serena Paladini, Kris Simone Tranches Dias, Ariele Faria dos Santos, Claudio Viegas, Ihosvany Camps, Letizia Pruccoli, Andrea Tarozzi, Patrizia Hrelia
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
amyloid-β oligomers
oxidative stress
apoptosis
neuroprotection
multitarget ligand
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00658/full

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