Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysis
<p>Abstract</p> <p>Background</p> <p>Recent developments related to a safe and effective nonabsorbable antibiotic, rifaximin, and identification of postinfectious irritable bowel syndrome as a frequent sequela call for a need to reconsider the value of primary preventio...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-08-01
|
| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | http://www.systematicreviewsjournal.com/content/1/1/39 |
| _version_ | 1811249061646303232 |
|---|---|
| author | Alajbegovic Sanjin Sanders John W Atherly Deborah E Riddle Mark S |
| author_facet | Alajbegovic Sanjin Sanders John W Atherly Deborah E Riddle Mark S |
| author_sort | Alajbegovic Sanjin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recent developments related to a safe and effective nonabsorbable antibiotic, rifaximin, and identification of postinfectious irritable bowel syndrome as a frequent sequela call for a need to reconsider the value of primary prevention of traveler’s diarrhea (TD) with antibiotics.</p> <p>Methods</p> <p>Randomized, placebo-controlled, double-blind studies evaluating the effectiveness and safety of rifaximin or a fluoroquinolone chemoprophylaxis against TD were pooled using a random effects model and assessed for heterogeneity.</p> <p>Results</p> <p>The nine studies (four rifaximin and five fluoroquinolone) included resulted in pooled relative risk estimates of 0.33 (95% CI = 0.24–0.45, <it>I</it><sup>2</sup> = 3.1%) and 0.12 (95% CI = 0.07–0.20, <it>I</it><sup>2</sup> =0.0%), respectively. Similar rates of treatment emergent adverse events were found between antibiotic and placebo groups.</p> <p>Conclusions</p> <p>This meta-analysis supports the effectiveness of antibiotics in preventing TD. However, further studies that include prevention of secondary chronic health outcomes among travelers to different geographic regions, and a formal risk-benefit analysis for antibiotic chemoprophylaxis, are needed.</p> |
| first_indexed | 2024-04-12T15:39:55Z |
| format | Article |
| id | doaj.art-5ce1ae7a128647428e71c13b0ab0e013 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-04-12T15:39:55Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-5ce1ae7a128647428e71c13b0ab0e0132022-12-22T03:26:50ZengBMCSystematic Reviews2046-40532012-08-01113910.1186/2046-4053-1-39Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysisAlajbegovic SanjinSanders John WAtherly Deborah ERiddle Mark S<p>Abstract</p> <p>Background</p> <p>Recent developments related to a safe and effective nonabsorbable antibiotic, rifaximin, and identification of postinfectious irritable bowel syndrome as a frequent sequela call for a need to reconsider the value of primary prevention of traveler’s diarrhea (TD) with antibiotics.</p> <p>Methods</p> <p>Randomized, placebo-controlled, double-blind studies evaluating the effectiveness and safety of rifaximin or a fluoroquinolone chemoprophylaxis against TD were pooled using a random effects model and assessed for heterogeneity.</p> <p>Results</p> <p>The nine studies (four rifaximin and five fluoroquinolone) included resulted in pooled relative risk estimates of 0.33 (95% CI = 0.24–0.45, <it>I</it><sup>2</sup> = 3.1%) and 0.12 (95% CI = 0.07–0.20, <it>I</it><sup>2</sup> =0.0%), respectively. Similar rates of treatment emergent adverse events were found between antibiotic and placebo groups.</p> <p>Conclusions</p> <p>This meta-analysis supports the effectiveness of antibiotics in preventing TD. However, further studies that include prevention of secondary chronic health outcomes among travelers to different geographic regions, and a formal risk-benefit analysis for antibiotic chemoprophylaxis, are needed.</p>http://www.systematicreviewsjournal.com/content/1/1/39Travelers’ diarrheaChemoprophylaxisSystematic reviewMeta-analysisRifaximinFluoroquinolone |
| spellingShingle | Alajbegovic Sanjin Sanders John W Atherly Deborah E Riddle Mark S Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysis Systematic Reviews Travelers’ diarrhea Chemoprophylaxis Systematic review Meta-analysis Rifaximin Fluoroquinolone |
| title | Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysis |
| title_full | Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysis |
| title_fullStr | Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysis |
| title_full_unstemmed | Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysis |
| title_short | Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysis |
| title_sort | effectiveness of rifaximin and fluoroquinolones in preventing travelers diarrhea td a systematic review and meta analysis |
| topic | Travelers’ diarrhea Chemoprophylaxis Systematic review Meta-analysis Rifaximin Fluoroquinolone |
| url | http://www.systematicreviewsjournal.com/content/1/1/39 |
| work_keys_str_mv | AT alajbegovicsanjin effectivenessofrifaximinandfluoroquinolonesinpreventingtravelersdiarrheatdasystematicreviewandmetaanalysis AT sandersjohnw effectivenessofrifaximinandfluoroquinolonesinpreventingtravelersdiarrheatdasystematicreviewandmetaanalysis AT atherlydeborahe effectivenessofrifaximinandfluoroquinolonesinpreventingtravelersdiarrheatdasystematicreviewandmetaanalysis AT riddlemarks effectivenessofrifaximinandfluoroquinolonesinpreventingtravelersdiarrheatdasystematicreviewandmetaanalysis |