Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile

Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile

The pathogenicity locus (PaLoc) of Clostridioides difficile usually comprises five genes (tcdR, tcdB, tcdE, tcdA, tcdC). While the proteins TcdA and TcdB represent the main toxins of this pathogen, TcdR and TcdC are involved in the regulation of their production. TcdE is a holin family protein, memb...

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Bibliographic Details
Main Authors: Denise Mehner-Breitfeld, Claudia Rathmann, Thomas Riedel, Ingo Just, Ralf Gerhard, Jörg Overmann, Thomas Brüser
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Microbiology
Subjects:
Clostridioides difficile
toxins
holins
endolysins
protein transport
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02446/full

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