Sequence-structure functional implications and molecular simulation of high deleterious nonsynonymous substitutions in IDH1 revealed the mechanism of drug resistance in glioma

Sequence-structure functional implications and molecular simulation of high deleterious nonsynonymous substitutions in IDH1 revealed the mechanism of drug resistance in glioma

In the past few years, various somatic point mutations of isocitrate dehydrogenase (IDH) encoding genes (IDH1 and IDH2) have been identified in a broad range of cancers, including glioma. Despite the important function of IDH1 in tumorigenesis and its very polymorphic nature, it is not yet clear how...

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Bibliographic Details
Main Authors: Muhammad Suleman, Syeda Umme-I-Hani, Muhammad Salman, Mohammed Aljuaid, Abbas Khan, Arshad Iqbal, Zahid Hussain, Syed Shujait Ali, Liaqat Ali, Hassan Sher, Yasir Waheed, Dong-Qing Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
nsSNPs
IDH1
molecular docking
simulation
binding free energy
introduction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.927570/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.927570/full

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