Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among othe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12215 |
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| author | Francisco Javier Manzano-Moreno Victor J. Costela-Ruiz Enrique García-Recio Maria Victoria Olmedo-Gaya Concepción Ruiz Candelaria Reyes-Botella |
| author_facet | Francisco Javier Manzano-Moreno Victor J. Costela-Ruiz Enrique García-Recio Maria Victoria Olmedo-Gaya Concepción Ruiz Candelaria Reyes-Botella |
| author_sort | Francisco Javier Manzano-Moreno |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs. |
| first_indexed | 2024-03-10T05:26:32Z |
| format | Article |
| id | doaj.art-5ceabb4da63340ffb19057057c765fa4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:26:32Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5ceabb4da63340ffb19057057c765fa42023-11-22T23:38:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221221510.3390/ijms222212215Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell CarcinomaFrancisco Javier Manzano-Moreno0Victor J. Costela-Ruiz1Enrique García-Recio2Maria Victoria Olmedo-Gaya3Concepción Ruiz4Candelaria Reyes-Botella5Biomedical Group (BIO277), Department of Stomatology, School of Dentistry, University of Granada, 18071 Granada, SpainInstituto Investigación Biosanitaria, ibs.Granada, 18071 Granada, SpainInstituto Investigación Biosanitaria, ibs.Granada, 18071 Granada, SpainDepartment of Stomatology, School of Dentistry, University of Granada, 18071 Granada, SpainInstituto Investigación Biosanitaria, ibs.Granada, 18071 Granada, SpainBiomedical Group (BIO277), Department of Stomatology, School of Dentistry, University of Granada, 18071 Granada, SpainOral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs.https://www.mdpi.com/1422-0067/22/22/12215salivary biomarkermicroRNAcytokinesoral pathologydiagnosisoral cancer |
| spellingShingle | Francisco Javier Manzano-Moreno Victor J. Costela-Ruiz Enrique García-Recio Maria Victoria Olmedo-Gaya Concepción Ruiz Candelaria Reyes-Botella Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma International Journal of Molecular Sciences salivary biomarker microRNA cytokines oral pathology diagnosis oral cancer |
| title | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
| title_full | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
| title_fullStr | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
| title_short | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
| title_sort | role of salivary microrna and cytokines in the diagnosis and prognosis of oral squamous cell carcinoma |
| topic | salivary biomarker microRNA cytokines oral pathology diagnosis oral cancer |
| url | https://www.mdpi.com/1422-0067/22/22/12215 |
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